ITGAV在结直肠癌中的表达及临床意义

doi:10.3969/j.issn.1009-976X.2021.03.011

岭南现代临床外科 ›› 2021, Vol. 21 ›› Issue (03): 309-312.DOI: 10.3969/j.issn.1009-976X.2021.03.011

ITGAV在结直肠癌中的表达及临床意义

曾兵^1,2, 李锦宏², 蔡灿锋², 辛海洋², 曾军²

1.中山大学附属第六医院胃肠、疝和腹壁外科,广州 510655;
2.广州医科大学附属第六医院普通外科,广东清远 511518

通讯作者: 曾兵,Email：zengbing3@mail.sysu.edu.cn
基金资助:
国家自然科学基金（81973858）; 广东省中医药局科研课题（20191401）; 清远市科技计划项目（2019A028、2018B030）

The expression and clinical significance of ITGAV in colorectal cancer

ZENG Bing^1,2, LI Jin-hong², CAI Can-feng², XIN Hai-yang², ZENG Jun²

1. Department of Gastroenterology, Hernia and Abdominal Wall Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655;
2. Department of General Surgery, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People′s Hospital, Qingyuan, Guangdong 511518, China

Received:2021-01-08 Online:2021-06-20 Published:2021-08-20

摘要/Abstract

摘要： 目的探讨整合素αv（ITGAV）在结直肠癌中的表达和临床意义。方法采用免疫组织化学法检测91例结直肠癌组织及18例癌旁组织中ITGAV的表达,分析ITGAV的表达与临床病理因素的关系。利用GEO和TCGA数据库下载结直肠癌ITGAV的表达及临床随访数据进行生存分析。结果 ITGAV在结直肠癌组织中的表达显著高于癌旁组织,差异有统计学意义（P<0.05）。91例结直肠癌组织中ITGAV高表达组有61例,低表达组有30例。ITGAV的表达与脉管神经侵犯、浸润深度、淋巴结转移、远处转移及TNM分期相关（P<0.05）,与性别、年龄、肿瘤部位及分化程度无明显相关（P>0.05）。生存分析显示ITGAV高表达组患者总生存率显著低于低表达组（P<0.05）。结论 ITGAV高表达与结直肠癌的侵袭转移及预后不良相关。

关键词: 整合素αv, 结直肠癌, 预后

Abstract: Objective To investigate the expression and clinical significance of integrin αv （ITGAV） in colorectal cancer. Methods Immunohistochemical method was used to detect the expression of ITGAV in 91 cases of colorectal cancer tissues and 18 cases of adjacent tissues, and the relationship between the expression of ITGAV and clinicopathological factors was analyzed. The expression of ITGAV mRNA in colorectal cancer and clinical follow up data was download from GEO and TCGA databases, and Kaplan-Meier method was used for survival analysis. Results The expression of ITGAV in colorectal cancer tissues was significantly higher than that in adjacent tissues, and the difference was statistically significant （P<0.05）. Among 91 cases of colorectal cancer, there were 61 cases in the high expression group of ITGAV and 30 cases in the low expression group. The expression of ITGAV was related to vascular nerve invasion, depth of invasion, lymph node metastasis, distant metastasis and TNM staging （P<0.05）, but not significantly related to gender, age, tumor location and degree of differentiation （P>0.05）. Survival analysis showed that the overall survival rate of patients in the high expression group of ITGAV was significantly lower than that in the low expression group （P<0.05）. Conclusion High expression of ITGAV is associated with the invasion, metastasis and poor prognosis of colorectal cancer.

Key words: integrin αv, colorectal cancer, prognosis

中图分类号:

曾兵, 李锦宏, 蔡灿锋, 辛海洋, 曾军. ITGAV在结直肠癌中的表达及临床意义[J]. 岭南现代临床外科, 2021, 21(03): 309-312.

ZENG Bing, LI Jin-hong, CAI Can-feng, XIN Hai-yang, ZENG Jun. The expression and clinical significance of ITGAV in colorectal cancer[J]. Lingnan Modern Clinics In Surgery, 2021, 21(03): 309-312.

参考文献

[1] Desgrosellier JS, Cheresh DA.Integrins in cancer: biological implications and therapeutic opportunities[J]. Nat Rev Cancer, 2010, 10(1): 9-22.
[2] Liu G, Zhu J, Yu M, et al.Glutamate dehydrogenase is a novel prognostic marker and predicts metastases in colorectal cancer patients[J]. J Transl Med, 2015, 13: 144.
[3] Sung H, Ferlay J, Siegel RL, et al.Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249.
[4] Li L, Bao J, Wang H, et al.Upregulation of amplified in breast cancer 1 contributes to pancreatic ductal adenocarcinoma progression and vulnerability to blockage of hedgehog activation[J]. Theranostics, 2021, 11(4): 1672-1689.
[5] Hoshino A, Costa-Silva B, Shen TL, et al.Tumour exosome integrins determine organotropic metastasis[J]. Nature, 2015, 527(7578): 329-335.
[6] Loeser H, Scholz M, Fuchs H, et al.Integrin alpha V (ITGAV) expression in esophageal adenocarcinoma is associated with shortened overall-survival[J]. Sci Rep, 2020, 10(1): 18411.
[7] 李峰, 王婧婷, 鲁建光, 等. 整合素αv亚家族与喉鳞状细胞癌侵袭转移的相关性研究[J]. 哈尔滨医科大学学报, 2019, 53(5): 489-493.
[8] Chen JS, Hsu YM, Chen CC, et al.Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression[J]. J Biol Chem, 2010, 285(33): 25458-25466.
[9] Waisberg J, De Souza Viana L, Affonso Junior RJ, et al. Overexpression of the ITGAV gene is associated with progression and spread of colorectal cancer[J]. Anticancer Res, 2014, 34(10): 5599-5607.
[10] Flum M, Kleemann M, Schneider H, et al.miR-217-5p induces apoptosis by directly targeting PRKCI, BAG3, ITGAV and MAPK1 in colorectal cancer cells[J]. J Cell Commun Signal, 2018, 12(2): 451-466.

[1]	何冲, 周姝睿, 李雅晴, 陈少杰, 练国达, 陈尚祥, 黄开红. 胰腺癌预后相关铁死亡基因筛选及预后预测模型构建[J]. 岭南现代临床外科, 2022, 22(1): 14-23.
[2]	刘伟. 恶性脑胶质瘤单放和放化疗临床疗效5年随诊分析[J]. 岭南现代临床外科, 2022, 22(1): 89-93.
[3]	胡明超, 朱宝松. NDC1基因在结肠癌中诊断及预后价值的生物信息学分析：一项基于TCGA数据库的研究[J]. 岭南现代临床外科, 2021, 21(06): 598-602.
[4]	徐润强, 刘宇平, 张海良, 刘海盛, 刘钰君, 姚金科. VEGF-A及PI3K/AKT通路在结直肠癌中的表达及临床意义[J]. 岭南现代临床外科, 2021, 21(06): 603-607.
[5]	宋燕州, 康志龙, 苏一男, 张毅明, 赵新, 李志伟, 李伟. NEK7在原发性肝细胞肝癌患者中表达及其临床意义[J]. 岭南现代临床外科, 2021, 21(06): 608-613.
[6]	唐兴奎, 林玉坤, 何嘉琳, 罗喜俊, 梁俊杰, 朱显军. 广泛型线粒体肌酸激酶基因在结直肠癌中的表达及生物学意义[J]. 岭南现代临床外科, 2021, 21(05): 535-540.
[7]	王道笃, 赵其炯, 周志标, 何永越. 基于铁死亡相关基因构建肝细胞癌的预后模型[J]. 岭南现代临床外科, 2021, 21(04): 419-424.
[8]	王庆斌, 商昌珍, 陈亚进. 肝癌切除术后预后预测的研究进展[J]. 岭南现代临床外科, 2021, 21(04): 471-476.
[9]	朱钊雯, 贾卫娟, 刘洁琼. Luminal型乳腺癌胞膜蛋白相关预后模型的构建与验证[J]. 岭南现代临床外科, 2021, 21(03): 281-286.
[10]	伍隽华, 陈云扬, 张鑫, 余杰雄, 崔恩铭, 张慧玲. 肝癌患者中RNF24的表达及临床价值[J]. 岭南现代临床外科, 2021, 21(02): 165-170.
[11]	张果, 张瑞, 陈进宏. 结直肠癌肝转移预后评分系统的现状及临床应用[J]. 岭南现代临床外科, 2021, 21(01): 11-16.
[12]	霍励耘, 魏英城, 谭文亮, 商昌珍, 陈亚进. SMC基因家族在肝癌中的表达及其预测肝癌预后的临床意义[J]. 岭南现代临床外科, 2021, 21(01): 24-28.
[13]	黄贻培, 罗伟鑫, 许磊波. 转录因子YY1在肝细胞癌中的表达和功能研究[J]. 岭南现代临床外科, 2021, 21(01): 44-52.
[14]	任宝军, 剧永乐, 封静, 陈淑香, 刘家旋, 罗振涛, 王家智, 杨帆, 李德智, 董博业, 耿岩. Aurora A激酶抑制剂Alisertib诱导结直肠癌细胞自噬的作用及与p53表达间的关系[J]. 岭南现代临床外科, 2021, 21(01): 82-86.
[15]	张华耀, 许水英, 林思园, 张利华, 张致远, 梁宝珍, 刘颖升, 李想娣. 年轻乳腺癌的临床病理特点及预后因素分析：基于SEER数据库的回顾性研究[J]. 岭南现代临床外科, 2021, 21(01): 91-95.

ITGAV在结直肠癌中的表达及临床意义

The expression and clinical significance of ITGAV in colorectal cancer

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics