铜绿假单胞菌注射液在单纯性乳腺囊肿治疗中的应用

doi:10.3969/j.issn.1009-976X.2021.01.017

摘要/Abstract

摘要： 目的通过观察铜绿假单胞菌注射液（PA-MSHA）对乳腺囊肿的治疗效果,探讨PA-MSHA在单纯性乳腺囊肿治疗中的应用价值。方法将120例单纯性乳腺囊肿患者随机分为3组,每组40例。A组于超声引导囊肿穿刺抽液后注入PA-MSHA,B组于抽液后注入无水乙醇,C组于抽液后注入高渗糖水,记录各组患者治疗期间的不良反应并随访24个月,对3组治疗期间的不良反应及治疗效果进行对比。结果 120例患者均完成治疗,其中113例完成随访,失访7例。术后6、12、24个月,各组间的治疗效果无明显统计学差异（P > 0.10）。A、B、C组治疗期间均出现不良反应,其中A组不良反应率明显低于B、C组,差异具有统计学意义（P < 0.016）。结论超声引导下囊肿穿刺抽液后注射铜绿假单胞菌注射液可有效治疗单纯性乳腺囊肿,不良反应少,具有临床应用价值。

关键词: 单纯性乳腺囊肿, 铜绿假单胞菌注射液, 无水乙醇, 高渗糖水

Abstract: Objective To observe the efficacy of pseudomonas aeruginosa-mannose sensitive hemagglutinin （PA-MSHA） in the treatment of simple breast cysts, and to investigate the value of piliated pseudomonas aeruginosa in treating simple breast cysts. Methods 120 cases were divided into 3 groups, each group contained 40 cases. Cases in group A, B and C were treated with ultrasound guided suction combined with injection of PA-MSHA, ethanol and hypertonic sugar, respectively. Adverse effects of each group were observed and recorded. All cases were followed-up for about 24 months. The curative effect and side-effects of treatment were compared between the three groups. Results All cases have completed these treatments successfully. 113 patients were followed-up for about 24 months, while 7 cases were lost. There was no statistical significance difference between the three groups comparing the curative effect （P > 0.10）. Adverse effects were observed in all groups during treatment. The rate of adverse effects of group A was lower than group B and C. There was statistical significance difference between group A and the other two groups （P < 0.016）. Conclusion The ultrasound guided suction combined with injection of pseudomonas aeruginosa-mannose sensitive hemagglutinin has a prominent effect in the treatment of simple breast cysts and the adverse events are rare. The application of pseudomonas aeruginosa-mannose sensitive hemagglutinin in the treatment of simple breast cysts is valuable.

Key words: simple breast cysts, pseudomonas aeruginosa-mannose sensitive hemagglutinin, ethanol, hypertonic sugar

中图分类号:

R655.8

李俊达, 张俊琳, 林启谋. 铜绿假单胞菌注射液在单纯性乳腺囊肿治疗中的应用[J]. 岭南现代临床外科, 2021, 21(01): 96-99.

LI Jun-da, ZHANG Jun-lin, LIN Qi-mou. Application of pseudomonas aeruginosa-mannose sensitive hemagglutinin in treatment of simple breast cysts[J]. Lingnan Modern Clinics In Surgery, 2021, 21(01): 96-99.

参考文献

[1] Enriori PJ, Vazquez SM, Chiauzzi V, et al.Breast cyst fluids increase the proliferation of breast cell lines in correlation with their hormone and growth factor concentration[J]. Clin Endocrinol, 2006, 64(1): 20-28.
[2] Gomes C, Amaral N, Marques C, et al.Sclerosis of gross cysts of the breast: a three-year study[J]. Eur J Gynaecol Oncol, 2002, 23(3): 191-194.
[3] Ozgen A.Effectiveness of single-session ultrasound-guided percutaneous ethanol sclerotherapy in simple breast cysts[J]. Diagn Interv Radiol, 2016, 22(3): 220-223.
[4] Lv F, Cao J, Liu Z, et al.Phase II study of Pseudomonas aeruginosa-Mannose-Sensitive hemagglutinin in combination with capecitabine for Her-2-negative metastatic breast cancer pretreated with anthracycline and taxane[J]. PLoS One, 2015, 10(3): e118607.
[5] Liu J, Duan X.PA-MSHA induces apoptosis and suppresses metastasis by tumor associated macrophages in bladder cancer cells[J]. Cancer Cell Int, 2017, 17: 76.
[6] Genpeng L, Jinen S, Tao W, et al.Intraoperative application of inactivated Pseudomonas aeruginosa in patients undergoing lateral neck dissection for metastatic thyroid cancer: A randomized, parallel group, placebo-controlled trial[J]. Surgery, 2020, 168(2): 340-346.
[7] 吴汉生, 王伟森, 肖大伟, 等. 铜绿假单胞菌注射液对难治性气胸的疗效评价[J]. 汕头大学医学院学报, 2018, 31(4): 224-226.
[8] 李伟兰, 陈彩云, 罗樱, 等. 超声引导穿刺抽液联合不同硬化剂治疗单纯性乳腺囊肿的应用[J]. 中国医学影像学杂志, 2016, 24(12): 903-905.
[9] Zhang M, Luo F, Zhang Y, et al.Pseudomonas aeruginosa mannose-sensitive hemagglutinin promotes T-cell response via toll-like receptor 4-mediated dendritic cells to slow tumor progression in mice[J]. J Pharmacol Exp Ther, 2014, 349(2): 279-287.
[10] Li T, Dong ZR, Guo ZY, et al.Mannose-mediated inhibitory effects of PA-MSHA on invasion and metastasis of hepatocellular carcinoma via EGFR/Akt/IkappaBbeta/NF-kappaB pathway[J]. Liver Int, 2015, 35(4): 1416-1429.
[11] Zhang C, Zhang Z, Wang L, et al.Pseudomonas aeruginosa-mannose sensitive hemagglutinin injection treated cytokine-induced killer cells combined with chemotherapy in the treatment of malignancies[J]. Int Immunopharmacol, 2017, 51: 57-65.
[12] Wei T, Liu F, Li Z, et al.Novel Management of Intractable Cervical Chylous Fistula with Local Application of Pseudomonas aeruginosa Injection[J]. Otolaryngol Head Neck Surg, 2015, 153(4): 561-565.
[13] Chen Q, Zou X, Ma Y, et al.Pseudomonas aeruginosa-mannose sensitive hemagglutinin injection therapy for the treatment of chyle fistula following neck dissection[J]. Head Neck, 2020, 42(4): 725-731.
[14] Ma FY, Wang LQ, Wang CL, et al.Clinical application of piliated pseudomonas aeruginosa for breast cancer patients after operation with seroma formation[J]. Chin J Cancer Prev Treat, 2009, 14(16): 1111-1112.

[1]	欧欣瑜, 陆艺文, 刘志瀚, 苏士成. 术中导航系统在腔镜乳腺癌保乳根治术中的应用：病例报告[J]. 岭南现代临床外科, 2022, 22(1): 1-5.
[2]	杨剑敏, 邹素文, 李敏滢, 区俏彦. 乳腺纤维腺瘤真空辅助旋切与开放手术对泌乳功能的影响[J]. 岭南现代临床外科, 2021, 21(06): 636-639.
[3]	吴卓鹏, 杨劼. 胸外科手术后继发乳糜胸的防治[J]. 岭南现代临床外科, 2021, 21(06): 688-692.
[4]	茹扎, 胡瑛, 黄胜华, 白莉, 朱蕾. 聚丙烯酰胺水凝胶注射隆乳术后少见多重类型并发症一例[J]. 岭南现代临床外科, 2021, 21(04): 467-470.
[5]	王闯, 周晓华, 曾宪成, 谭硕果, 梁永艺, 刘建平. 真空辅助系统治疗乳腺良性肿瘤的临床实践[J]. 岭南现代临床外科, 2021, 21(03): 325-328.
[6]	杨剑敏, 余海云, 于海静, 王永南. 肉芽肿性乳腺炎激素治疗后微创手术与开放手术治疗的对照研究[J]. 岭南现代临床外科, 2021, 21(02): 192-194.
[7]	冯瑞卿, 傅仲带, 曹磊, 欧妍妍, 黄健东. 三种保守方法在治疗乳腺纤维囊性病中的临床观察和体会[J]. 岭南现代临床外科, 2021, 21(02): 204-208.
[8]	孔恒, 陈继鑫. 超声诊断困难的原发性乳腺血管肉瘤：一例报告及文献综述[J]. 岭南现代临床外科, 2021, 21(01): 104-107.
[9]	张华耀, 叶华, 林思园, 刘海平, 张致远, 李想娣, 梁宝珍, 张利华. 左氧氟沙星联合利福平治疗哺乳期乳腺脓肿MRSA感染的临床分析及研究[J]. 岭南现代临床外科, 2020, 20(04): 440-443.
[10]	甄乐锋，陈晓明，黄涛，王金重，文达辉. 麦默通旋切活检和金属导丝定位活检在临床触诊阴性乳腺病灶活检中的应用对比[J]. 岭南现代临床外科, 2019, 19(03): 289-292.
[11]	张凯，罗智辉，黄湛，宫绪萌. 外科手术治疗肉芽肿性小叶乳腺炎患者的临床观察[J]. 岭南现代临床外科, 2019, 19(02): 177-181.
[12]	谷佃宝张健桑节峰夏扣柱刘斌. 乳腺癌改良根治术保留肋间臂神经对患者临床症状及远期生活质量的影响[J]. 岭南现代临床外科, 2017, 17(05): 543-550.
[13]	彭健雄梁燕芬陈梦丽钟晓丹杨玲玲林子雄. 中西医结合治疗哺乳期早期乳腺炎疗效分析[J]. 岭南现代临床外科, 2017, 17(04): 474-476.
[14]	张晓叶一峰. 软组织扩张器在乳腺癌假体乳房重建术中的应用[J]. 岭南现代临床外科, 2017, 17(02): 194-197.
[15]	程斌程海燕吕园园. 三氧包裹在乳腺脓肿中的应用[J]. 岭南现代临床外科, 2016, 16(05): 586-588.