SMC基因家族在肝癌中的表达及其预测肝癌预后的临床意义

doi:10.3969/j.issn.1009-976X.2021.01.005

摘要/Abstract

摘要： 目的研究SMC基因家族在肝癌组织中的表达水平,及其与肝癌分期和预后的相关性。方法应用UALCAN和Human Protein Atlas数据库,分析SMC基因家族在肝癌组织和正常肝组织的表达水平,并进一步分析其在肝癌不同分期中的转录水平。利用GEPIA数据库完成对SMC家族各成员基因与肝癌的生存预后相关性分析。结果与正常肝组织比较,SMC基因家族成员在肝癌组织中高表达（肝癌 vs. 正常肝组织,P<0.0001）,其转录水平也与肿瘤的分期有关。SMC1A、SMC1B、SMC2、SMC3、SMC4、SMC5和SMC6在Ⅲ期肝癌中的表达显著高于Ⅰ期肝癌（Ⅲ期 vs.Ⅰ期,P<0.05）,SMC1A和SMC2在Ⅱ期肝癌患者中的表达高于Ⅰ期肝癌（Ⅰ期 vs.Ⅱ期,P<0.05）。此外,在肝癌的生存分析中显示,SMC1A、SMC2、SMC3、SMC4、SMC6高表达患者的预后较差（P<0.05）,其总生存期（OS）或无瘤生存期（DFS）明显短于低表达组。结论 SMC基因家族在肝癌组织中高表达,其中SMC1A、SMC2、SMC3、SMC4、SMC6的表达与肝癌患者预后不良呈正相关,可以作为肝癌预后预测因素。

关键词: SMC基因家族, 肝癌, 预后, 生物信息学分析

Abstract: Objective To explore the relationship between SMCs and the progression of hepatocellular carcinoma （HCC） by bioinformatics analysis, and to explore the clinical significance of SMCs in the diagnosis and prognosis of HCC. Methods In this study, UALCAN and Human Protein Atlas datasets were used to analyze the expression of SMCs in hepatocellular carcinoma and normal liver tissues, as well as its transcriptional level in various stages of hepatocellular carcinoma. After that, we used the GEPIA database to explore the survival curves of SMCs in HCC patients. Results We found that SMCs were highly expressed in HCC tissues （tumor vs. normal, P value <0.0001）, and their transcriptional levels were also related to the tumor stages. The transcriptions of SMC1A, SMC1B, SMC2, SMC3, SMC4, SMC5 and SMC5 in stage 3 liver hepatocellular carcinoma were significantly higher than those in stage1 （stage 1 vs. stage3, P value <0.05）. The expression levels of SMC1A and SMC2 in stage 2 liver hepatocellular carcinoma were stimulated, comparing to their transcription levels in stage 1 （stage 1 vs. stage 2, P value <0.05）. In addition, the survival analysis showed that higher expression of SMC1A, SMC2, SMC3, SMC4 and SMC6 was significantly related to poorer prognosis （P value <0.05）. Conclusion SMCs were highly expressed in HCC tissues and were associated with tumor stages. SMC1A, SMC2, SMC3, SMC4 and SMC6 showed significant value in the diagnosis and prognosis of HCC.

Key words: SMC gene family, hepatocellular carcinoma, prognosis, bioinformatics analysis

中图分类号:

R735.7

霍励耘, 魏英城, 谭文亮, 商昌珍, 陈亚进. SMC基因家族在肝癌中的表达及其预测肝癌预后的临床意义[J]. 岭南现代临床外科, 2021, 21(01): 24-28.

HUO Li-yun, WEI Ying-cheng, TAN Wen-liang, SHANG Chang-zhen, CHEN Ya-jin. The clinical significance of SMC gene family in the diagnosis and prognosis of hepatocellular carcinoma[J]. Lingnan Modern Clinics In Surgery, 2021, 21(01): 24-28.

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