关键词: 深静脉穿刺置管, 纳布啡, 静脉麻醉, 丙泊酚, 小儿

Abstract: Objective To evaluate the value of propofol combined with nabulphineanesthesia on central venus catheterization in children with hematologic diseases. Methods A total of 60 children with hematologic diseases underwent central venus catheterization in the operating room were randomly divided into the observation group （propofol combined with nabophine） and the control group （propofol alone）, with 30 patients in each group. Children in the observation group were anesthetized with propofol combined with nalbuphine, while children in the control group were anesthetized with propofol alone. Propofol dosage, the incidence of body movement during puncture, the incidence of respiratory depression, operative time and waking time were compared between the two groups. Restlessness and sedation scores were recorded immediately after wakefulness （T₁）, 30 min （T₂）, 2 h （T₃） and 6 h （T₄） postoperatively. The occurrence of postoperative adverse reactions in the two groups was recorded. Results The dosage of propofol, the incidence of body movement and the operation time of the patients in the control group were significantly higher than those in the observation group. There were no significant difference in the incidence of respiratory depression and waking time between the two groups. The restlessness and sedation scores of the observation group at T₁ and T₂ were better than those of the control group, and there was no statistically significant difference between the two groups at T₃ and T₄. There was no significant difference in postoperative adverse reactions between the two groups. Conclusion Propofol combined with nabulphine intravenous anesthesia is safe and feasible in central venus catheterization of children with hematologic diseases, which reduces the amount of intraoperative propofol, decreasesthe incidence of postoperative agitation, and does not affect the awake time of children.

Key words: intravenous anesthesia, central venus catheterization, children, propofol, nabulphine