关键词: 乌司他丁, 超氧化物歧化酶, 脑保护, 幕上肿瘤切除术, 丙二醛

Abstract: Objective To observe the concentration of superoxide dismutase （SOD）, malondialdehyde （MDA） in patients undergoing supratentorial tumor resection with Ulinastatin treatment. Methods 24 patients with supratentorial tumor resection,aged between 18 and 55 yeas old, ASAⅠorⅡ, were randomly divided into the control group （group A, n=12） and Ulinastatin groups （group U, n=12）. Patients in Group U received Ulinastatin （2 kU/kg） at the beginning of the surgery, with the continuous dose of 1 kU·kg^-1·h^-1 till the end of the operation. Group A received equivalent volume of saline solution as the vehilcle control. Blood samples were taken from the artery and jugular venous bulb before induction of anesthesia （T₁）, skin incision （T₂）,1 h after dura openning （T₃）, at the closure of dura （T₄）, at the end of operation （T₅）and 24 h after operation （T₆） to analysis the concentration of superoxide dismutase （SOD） andmalondialdehyde （MDA）. The concentration of superoxide dismutase （SOD）, malondialdehyde （MDA） were determined by improved hydroxylamine hydrochloride method and TAB fluorescence method. Results The concentration of serum MDA were more dramatic rise at T₃-T₆ than at T₁ in both groups. The concentration of serum SOD were more dramatic decline at T₃-T₆ than at T₁ in both groups. The concentration of SOD and MDA increasd and decreased significantly at T₃-T₆ in group U than that in group A （P<0.001）. Conclusion Ulinastatin can improve the concentration of serum SOD and decrease MDA during surgery, which indicates the alleviating for the brain injury during supratentorial tumor resection.

Key words: malondialdehyde, supratentorial tumor resection, ulinastatin, superoxidedismutase, cerebral protection