关键词: 碘营养, 成人, 广州, 尿碘, 甲状腺结节

Abstract: ［Abstract］ Objective To analyze the relationship between iodine nutritional status and clinical features of thyroid nodule disease in Guangzhou residents. Methods The adult population was collected from the Second Affiliated Hospital of Guangzhou Medical University from January 1， 2018 to February 1， 2019. Thyroid ultrasound， urinary iodine and thyroid function were detected in subjects. Urinary iodine <100 μg/L was for iodine insufficient group； urinary iodine 100-199 μg/L for iodine adequate group； urine iodine 200-299 μg/L for above requirement group； urine iodine > 300 μg/L for the iodine excess group. The relationship between urinary iodine and thyroid disease and thyroid function was explored. Results A total of 1107 patients were enrolled in the study， including 309 patients with thyroid nodules. The median urinary iodine was 93.40 μg/L. Compared with the iodine adequategroup，there was no significant difference in the rate of thyroid nodule disease in other groups. Besides， iodine nutrient had no significant effect on the prevalence of thyroid nodules complicated with hyperthyroidism or autoimmune thyroiditis. Compared with the iodine adequate group， iodine insufficient and iodine excess group showed significant higher FT3 and FT4 levels， and corresponding significantly lower TSH level. Conclusion The iodine nutrition of adults in Guangzhou is insufficient， and both iodine deficiency and iodine excess could lead to abnormal thyroid function.

Key words: adults, Guangzhou, urine iodine, iodine nutritional status, thyroid nodule