关键词: 凝固性血胸, 胸膜纤维板剥脱, 尿激酶

Abstract: ［Abstract］ Objective To evaluate the efficacy of urokinase intrathoracic perfusion therapy for early coagulated hemothorax after pleural dissection surgery. Methods Sixty?three patients with coagulated hemothorax after pleural exfoliation from March 2014 to December 2016 underwent urokinase intrathoracic perfusion. The thoracic drainage， X?ray examination results were recorded and comprehensively analyzed therapeutic effect. Results The perfusion process was smooth in all 63 patients， in which 48 cases were cured， 13 cases were effective and 2 cases were ineffective. The cure rate was 84.1% and the total effective rate was 96.8%. The patients were well tolerated during the whole treatment. Three cases had low fever， 8 had mild chest pain， 7 had shortness of breath and one case had massive hemorrhage， without other serious adverse reactions. Conclusion Treatment of early coagulated hemothorax with intrapleural perfusion of urokinase is a simple， safe， minimally invasive procedure， with definite efficacy， low incidence of adverse reactions.

Key words: urokinase, coagulated hemothorax, pleural decortications