关键词: 醛固酮瘤, 长链非编码RNA, 醛固酮

Abstract: ［Abstract］ Objective To study the differentially expressed long non?coding RNA （lncRNA） in aldosterone producing adenoma（APA） and analyse the role of lncRNA in the genesis and growth of APA. Methods Using microarray to find out the differentially expressed lncRNAs between the tumor and peritumor tissue of APA.After that， to discover the target lncRNAs through analysis and validate their expression levels. Analyzing the functions of target lncRNAs. Results Two lncRNAs?NR_040090 and T065445 were selected through the microarray and analysis. They were validated to be up?regulated in the tumor，and the consequences were the same as the microarray?s. From the results of lncRNA and mRNA co?expression and conjoint analysis， we can conclude that NR_040090 may be related to aldosterone synthesis， T065445 may have influence on aldosterone synthesis and adrenocortical cell proliferation which is responsible for tumorgenesis. Conclusion lncRNAs?NR_040090 and T065445 were up?regulated in APA tumor， NR_040090 may have relationship with aldosterone synthesis， T065445 may be associated with both aldosterone synthesis and tumorgenesis.

Key words: aldosterone producing adenoma（APA）, long non?coding RNA （lncRNA）, aldosterone