关键词: 成纤维生长因子23, 原发性醛固酮增多症, 钙磷代谢

Abstract: Objective To compare calcium and phosphorus metabolism and fibroblast growth factor 23（FGF23）level in patients with primary aldosteronism（PA）and essential hypertension（EH）, and to explore the correlation between them. Methods A total of 123 cases with PA and 123 cases with EH individually matched1：1 by gender, age, blood pressure and duration of hypertension were recruited from in-hospital patients who were hospitalized because of suspicion of secondary hypertension. The differences in calcium and phosphorus metabolism as well as FGF23 were compared between two groups. Result FGF23, PTH levels were higher in PA patient than that of EH patients, 271.31（173.91, 504.34）pg/mL vs. 160.41（118.08, 235.60）pg/mL, 74.5 pg/mL（46.5, 91.0）vs. 43.60（33.75, 60.25）pg/mL, P<0.001. However the levels of serum calcium and blood phosphorus were decreased in PA group, 2.18±0.17 vs. 2.33±0.17 mmol/L and 1.013±0.204 vs. 1.127±0.190 mmol/L, all P values <0.001. In PA group, FGF23 was negatively correlated with the level of serum phosphorus（r=- 0.502, P=0.001）, which was positively correlated with the PTH level（r=0.349, P=0.030）. With the increase of aldosterone level in PA group, FGF23 showed an upward trend（P<0.05）. Conclusion The level of FGF23 was significantly elevated in PA patients, and FGF23 was correlated with serum phosphorus and PTH levels. FGF23 may be associated with high aldosterone level.

Key words: calcium and phosphorusmetabolism, primary aldosteronism, fibroblast growth factor 23