关键词: 全髋关节置换术, D-二聚体 , 术中自体血回输, 凝血功能, 异体输血

Abstract: Objective To investigate the effect of different blood transfusion Methods on the coagulation function and the time effectiveness of D- dimer in patients undergoing total hip arthroplasty （THA）with moderate blood loss. Methods Using prospective caes control method ，according to the intraoperative blood loss +6 hours of drainage after surgery，the flow volume loss between the total 10%-20% screening condition，the first THA patients were selected and divided into two groups：autologous blood transfusion group （ABT group） and allogeneic blood transfusion group （group AT）. They were recorded before operation（T0），first days after operation（T1），3 days（T2），7 days（T3），14 days（T4） of the platelet count（PLT），prothrombin time（PT），prothrombin international ratio（INR），activated partial thromboplastin time（APTT），fibrinogen（FIB）and D-dimer（DD）. Results In group comparison，the effects of FIB and DD content at different time points were statistically significant （P<0.05）. Comparison between groups：through the interaction of treatment Methods ，the changes of PLT，PT， INR，APTT，FIB in the time points were not statistically significant （P>0.05）；DD content in T1 ，T2 time points were not statistically significant difference（P<0.05）. Conclusion Compared with allogeneic blood，intraoperative blood transfusion has the same influence on blood coagulation and thrombosis. The FIB and DD of the two groups showed regular changes after operation.

Key words: intraoperative blood transfusion, allogeneic blood, total hip arthroplasty, D-dimer, coagulation function