关键词: 阿托伐他汀, 疗效分析 , 钻孔引流术, 慢性硬膜下血肿

Abstract: Objective To compare the efficacy of oral atorvastatin calcium combined with drilling and drainage with simple drilling drainage in the treatment of chronic subdural hematoma（CSDH）. Methods The data of patients with chronic subdural hematoma treated by drilling and drainage were collected from Sun Yat-sen Memorial Hospital of Sun Yat- sen University and Guangdong Tongjiang Hospital from January 2016 to July 2017. Patients were divided into observation group（36 cases）and control group （32 cases） according to whether they aided oral administration of atorvastatin calcium tablets.In the observation group，the patients were treated with oral atorvastatin calcium for more than 8 weeks after drilling and drainage ，while the control group received drilling and drainage only. The treatment effect and Karnofsky（KPS）functional score were compared between the two groups. Results The total effective rate（97.22%）in the observation group was not significantly different from that in the control group （84.38%）（χ 2=2.062 ，P=0.151）. However ，the therapeutic efficacy of observation group was better than that of the control group（Z=- 2.413，P=0.016）. The recurrence rate in the observation group（0%）was lower than that in the observation group（12.5%）（χ2=4.711，P=0.03）. The KPS score at the 8th week after surgery was significantly higher in the observation group（92.78±9.74）than in the control group（87.19±12.50），with a significant difference（Z=-2.093，P=0.036）. Conclusion Atorvastatin combined with drilling and drainage shows better therapeutic efficacy and lower recurrence rate ， also helps patients in neurological recovery.

Key words: chronic subdural hematoma, atorvastatin, drill and drainage, efficacy analysis