Lynch 综合征相关结直肠癌患者临床特征

doi:10.3969/j.issn.1009-976X.2017.04.009

岭南现代临床外科 ›› 2017, Vol. 17 ›› Issue (04): 414-416.DOI: 10.3969/j.issn.1009-976X.2017.04.009

Lynch 综合征相关结直肠癌患者临床特征

田林

番禺中医院普外科

通讯作者: 田林

Clinical characteristics of Lynch syndrome-associated colorectal tumorigenesis

TIAN Lin

Department of General Surgery, Panyu Hospital of Chinese Medicine, Guangzhou 511470, China.

Online:2017-08-20 Published:2017-08-20

摘要/Abstract

摘要：

目的探讨Lynch综合征相关结直肠癌的临床特征。方法收集广州市番禺区中医院212例结直肠癌病例的临床资料与病理资料，通过免疫组化检测肿瘤组织的PMS2、MSH6、MLH1和MSH2，并结合临床资料进行统计分析。结果 212例结直肠癌患者中，共19例出现了MMR蛋白表达缺失，占8.96%。其中MLHl（-）/PMS2（-）7例，MSH2（-）/MSH6（-）5例，MSH6（-）3例，PMS2（-）4例。MMR蛋白表达缺失与患者年龄、肿瘤部位有关，与性别、肿瘤分化程度、TNM分期无关。结论 Lynch综合征相关结直肠癌好发于年轻患者与右半结肠。

关键词: 遗传性非息肉性, 免疫组织化学 , 结直肠肿瘤

Abstract:

Objective To investigate the clinical features of hereditary nonpolyposis cancer

（HNPCC） in Panyu District. The proteins of PMS2, MSH6, MLH1 and MSH2 in tumor tissues were detected by immunohistochemical assay. The detection Results combined with clinical data were analyzed statistically. Methods The clinical and pathological data of 212 patients with colorectal cancer were collected from Panyu District Hospital of Guangzhou. Results In 212 cases of colorectal cancer, 19 cases （8.96%）were found MMR protein loss, including MLHl（-）/PMS2（-）in 7 cases, MSH2（-）/MSH6（-） in 5 cases, MSH6（-）in 3 cases and PMS2（-）in 4 cases. The loss of MMR protein in colorectal cancers was associated with the patient’s age and sites of the tumors, not with sex, tumor differentiation and TNM staging. Conclusion The present data revealed that the Lynch syndrome occurred more often in younger patients with the right colon.

Key words: colorectal tumorigenesis, immunohistochemistry, hereditary nonpolyposis

中图分类号:

田林. Lynch 综合征相关结直肠癌患者临床特征[J]. 岭南现代临床外科, 2017, 17(04): 414-416.

TIAN Lin. Clinical characteristics of Lynch syndrome-associated colorectal tumorigenesis [J]. Lingnan Modern Clinics in Surgery, 2017, 17(04): 414-416.

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Lynch 综合征相关结直肠癌患者临床特征

Clinical characteristics of Lynch syndrome-associated colorectal tumorigenesis

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