关键词: 胶质瘤, 恶性程度, 预后 , G0S2基因

Abstract:

Objective To analyze the correlation between G0S2（G0S2G0/G1 switch 2）gene and glioma prognosis and malignancy. Methods The GSE33331 chip was analyzed by bioinformatics technique and the differential expression gene G0S2 was obtained. GO （Gene Ontology） analysis and survival analysis of G0S2 gene were performed using DAVID and TCGA database（The Cancer Genome Atlas）. The correlation between G0S2 and glioma level was studied by real-time fluorescence quantitative PCR. Results Bioinformatics analysis showed that G0S2 was the third most significant gene in the chip （logFC=-2.53672, P<0.001）. The gene was involved in the metabolism of lipids and molecules, and the survival time of glioma patients with high expression of this gene was significantly decreased（Chisq=150, P<0.001）. In addition, 40 cases of glioma with qPCR results confirmed that G0S2 was differentially expressed in high and low grade gliomas （t=3.168, P=0.003）. Conclusion The expression level of G0S2 gene is related to the degree of malignancy and prognosis of glioma.

Key words: G0S2, malignant degree, prognosis, glioma