关键词: 重组牛碱性成纤维细胞生长因子凝胶, 肛瘘, 血管, 血管内皮细胞生长因子, 受体

Abstract:

Objective To investigate the effects of shellfish Fuxin gel（recombinant bovine basic fibroblast growth factor gel）on anal fistula wound，angiogenesis and vascular endothelial growth factor（VEGF）and its receptor（VEGFR?2）expression. Methods Sixty cases of post?operation of anal fistula thread?drawing from Jan 2013 to Dec 2016 were selected and divided into observation group （n=30）， treated with Bei Fuxin Gel，and control group （n=30），treated with Vaseline gauze. The number of capillaries and the expression level of VEGF and VEGFR?2 were detected in 7 days and 14 days after treatment. Results The number of capillaries，expression level of VEGF and VEGFR?2 of the observation group are much higher，with statistically significance（all P values <0.05）respectively. Related analysis showed that wound capillary number and VEGF expression was significantly positive correlated（r=0.714， P<0.05）， wound capillary number and VEGFR?2 expression was significantly positive correlation （r=0.652，P<0.05）. Conclusion Bei Fuxin Gel can promote angiogenesis on the wound after anal fistula surgery，accelerate the expression of VEGF and VEGFR?2. There was a significant positive correlation between the number of capillaries and VEGF，VEGFR?2 expression.

Key words: vascular endothelial growth factor, anal fistula, recombinant bovine basic fibroblast growth factor gel, blood vessels, receptor