关键词: 原发性甲亢, 腔镜, 创伤反应 , 双侧甲状腺次全切除

Abstract: 【Abstract】 Objective To evaluate the response to trauma in primary hyperthyroidism patients who underwent endoscopic thyroidectomy via breast approach. Methods Fifty?three patients with prima?ry hyperthyroidism patients，admitted from Oct 2015 to Oct 2016 and underwent bilateral subtotal thy?roidectomy，were assigned endoscopic thyroidectomy via breast approach group（ET，n=18），and con?ventional open thyroidectomy group （COT，n=35）. The responses to trauma were measured, including Hs?CRP，TNF?α and IL?6 in peripheral blood at 2 hours pre?operation and 24 hours post?operation. The systemic inflammatory response syndrome（SIRS）was assessed in two groups. Results The postopera?tive values of Hs?CRP，TNF?α and IL?6 were higher than preoperative values in ET group, as same as in COT group. However，the changes（△Hs?CRP，△TNF?α and △IL?6）before and after operation in two groups were no significant difference（P>0.05）. And the morbidity of post?operation SIRS was approxi?mate within the two different surgery ways （P>0.05）. Conclusion Both the endoscopic thyroidectomy and conventional open thyroidectomy caused patients trauma?associated inflammatory response. But there was no significant difference of the trauma effect between ET group and COT group. It is optional surgery for appropriate patients.

Key words: primary hyperthyroidism, thyroidectomy, endoscopic surgery, trauma effect