关键词: EGFL7, 舌鳞状细胞癌, 侵袭, 转移, p-FAK

Abstract: 【Abstract】 Objective To investigate the function of EGFL7 in the research of cell invasion and migration in tongue squamous carcinoma. Methods EGFL7 and TSCC cell line expression levels were examined by qRT-PCR in cancer tissue and normal tissue. The changes about cell invasion and migration were detected by Transwell assays. Western blotting was performed to study the expression of EGFL7. Results After transfection with EGFL7-siR, the expression of EGFL7 was significantly down-regulated （P<0.001）. The invasion and migration ability of SCC-9 was substantially inhibited by EGFL7-siR. Western blotting showed that EGFL7 was found with positive expression in SCC-9. With downregulation of EGFL7，the expression of p-FAK was up-regulated substantially in SCC-9. Conclusion Overexpression of EGFL7 played an important role in the process of invasion and migration in SCC-9. Downregulation of EGFL7 in SCC-9 could substantially suppress its ability of cell invasion and migration. EGFL7 may exert its role by regulating the expression of p-FAK.

Key words: p-FAK, Invasion, Migration, Tongue squamous carcinoma, EGFL7