关键词: 前列腺特异性抗原密度(PSAD), 前列腺癌, 前列腺特异性抗原(PSA), ROC曲线

Abstract: 【Abstract】〓Objective〓To investigate the significance of prostate-specific antigen density (PSAD) for detecting prostate cancer in patients with a PSA between 2.5-10.0 ng/ml and 10.1-20.0 ng/ml. Methods〓461 men with a PSA between 2.5-20.0 ng/ml, underwent prostatic biopsy at two centers in Guangzhou, were retrospectively studied, and were divided into two groups (PSA 2.5-10.0 ng/ml vs. PSA10.1-20.0 ng/ml). Receiver operating characteristic (ROC) curve was used to evaluate the efficacy of PSA and PSAD for the diagnosis. Results〓In men with a PSA of 2.5-10.0 or 10.1-20.0 ng/ml, the areas under the ROC curve (AUCs) were higher for PSAD than for PSA. The optimal PSAD cut-off for predicting prostate cancer in men with a PSA of 2.5-10.0 ng/ml was 0.15 ng/ml/ml, with a sensitivity of 64.4% and specificity of 64.6%. The optimal cut-off for PSAD in men with a PSA of 10.1-20.0 ng/ml was 0.33 ng·ml-1·ml-1,with a sensitivity of 60.3% and specificity of 82.7%. Conclusion〓PSAD is illuminated a predictor of prostate cancer in patients with PSA between 2.5-10.0 ng/ml and 10.1-20.0 ng/ml.

Key words: Prostate specific antigen, Receiver operating characteristic curve, Prostate specific antigen density, Prostate cancer