关键词: 舒芬太尼注射液, 食管胃底静脉曲张, 内镜, 盐酸羟考酮注射液

Abstract: 【Abstract】〓Objective〓To investigate the efficacy and safety of oxycodone hydrochloride injection combined with propofol or sufentanil in patients underwent esophageal gastric varices (EGV) ligation operation. Methods〓Forty-eight patients with EGV were divided into two groups (n=24 each), oxycodone hydrochloride injection group (group A) and sufentanil injection group (group B). Patients in group A were administrated in vein with 0.1 mg/kg of oxycodone, induced with propofol 2 mg/kg and maintained with 4-7 mg-1·kg-1·h-1 propofol. Patients in group B were administrated in vein with 1 μg/kg of sufentanil, induced with 2 mg/kg of propofol and maintained with 4-7 mg-1·kg-1·h-1 of propofol. MAP, HR, RR, SPO2, BLS were continuously monitored. Cough, respiratory depression, total dosage of propofol and postoperative 30 min pain score were recorded. Results〓There were no significant differences in MAP, HR, RR, SPO2 and BLS between two groups (all P values were more than 0.05). The rates of adverse effects such as cough, body movement, respiratory depression, total dosage of propofol and postoperative 30 min pain score in group A were significantly lower than that of group B (P<0.05). Conclusion〓In the present study, xycodone hydrochloride injection was a safer and more effective treatment in patient underwent EGV ligation operation.

Key words: Endoscopy, Oxycodone hydrochloride injection, Esophageal gastric varices, Sufentanil injection