关键词: Ki67, PgR, 乳腺癌, Luminal A, Luminal B, 无病生存

Abstract: 【Abstract】〓Objective〓The objective of this study was to analyze the prognostic significance of Ki67 and PgR in distinguishing Luminal breast cancers. Methods〓Patients with ER-positive and HER-2-negative invasive breast cancer who were treated from 2006 to 2012, were selected by searching breast cancer registries at Sun Yat-sen Memorial Hospital..Clinicopathologic characteristics and prognoses were collected. The primary end point was DFS (disease free survival) which was analyzed by Kaplan-Meier curve with log rank test or Breslow test. Cox proportional hazards model was used to balance the risk factors for prognosis. Results〓A total of 964 patients with invasive breast cancer were eligible for inclusion in this study. Ki67 was found to be of prognostic significance in univariate analysis and multivariate analysis, but PgR was not an independent risk factor. Patients with low-Ki67-level and low-PgR level had different prognoses with high-Ki67-level and high-PgR-level subtype. Conclusion〓In order to optimize management of ER-positive and HER-2-negative patients, we need to consult other clinicopathologic characteristics or multi-gene assay, especially for low-Ki67-level and low-PgR level subtype.

Key words: Ki67, PgR, Breast cancer, Luminal A, Luminal B, Disease free survival