关键词: 严重脓毒症, 血清降钙素原, 早期乳酸清除率

Abstract: 【Abstract】〓Objective〓To explore the PCT and lactate clearance in clinical value in patients with severe sepsis by monitoring changes serum PCT levels and arterial blood lactate. Methods〓The clinical data of 78 patients with severe sepsis admitted between June 2013 and May 2015 in SICU was analyzed retrospectively. APACHEⅡ score, the PCT and the lactate clearance after 6 hours were measured. The patients were divided into survival group (54 cases) and death group (24 cases) according to the disease outcome, and high lactate clearance group (58 cases) and low lactate clearance group (30 cases) according to lactate clearance rate (with 10% for the sector). The correlation of PCT and lactate clearance was analyzed. Results〓There was no statistical difference among those groups in age,.sex,.APACHEⅡ score and the baseline of lactate..The serum PCT levels and the number of septic shock cases in the death group was significantly higher than the survival group (P<0.05). 6 h lactate clearance rate in death group was significantly lower than the survival group (P<0.05). The cases of patients with septic shock and mortality in high lactate clearance rate group were significantly lower than low lactate clearance rate group (P<0.05). There were no correlations between PCT and lactate clearance in death group and survival group(r2=0.189, P>0.05; r2=0.133, P>0.05). Conclusion Both PCT and lactate clearance were important indications. However, there is no correlation between level of PCT with lactate clearance.

Key words: Early lactate clearance rate , Severe sepsis, Sepsis, SICU, Procalcitonin