关键词: 纳米碳, 载体, 乳腺癌, 化疗

Abstract: 【Abstract】〓Objective〓To observe the therapeutic efficacy of carbon nanoparticle loaded with 5-fluorouracil in treatment of breast cancer model with metastasized axillary lymph nodes. To probe into the efficacy of carbon nanoparticles using in chemotherapy of breast cancer as a drug carrier. Methods〓Thirty female New Zealand white rabbits were randomly and equally divided into three groups, text group, Ⅳ(intravenous) group, HI group, with 10 in each. VX2 tumor mass suspensions (1 ml) was injected into the mammary gland (Hypodermic) of each animal..Treatment was given while axillary lymph node enlarged and reached 5 mm in the maximum diameter..Animals in test group and HI group received a subcutaneous injection of 5-FU-carbon nanoparticle suspension and 5-FU solution, respectively, adjacent to the implanted tumor. The IV group received an auricular intravenous injection of 5-FU solution..The dose of 5-FU in each group was 25 mg/kg..Animals were killed after the treatment was given 5 days. Growth rate of tumor and lymph node was measured. Necrosis degree and apoptotic index of tumor and lymph node after treatment were observed and measured. Results〓The growth rate of test group was lower than the other groups,.while necrosis degree and apoptotic index were higher than the other groups. There was statistical significance difference between these three groups (P<0.05). Conclusion〓Carbon nanoparticle could improve the treatment efficacy of chemotherapy drug in axillary metastatic lymph node of breast cancer.

Key words: Carbon nanoparticle, Drug carrier, Breast cancer, Chemotherapy