关键词: 生长激素腺瘤, 生长激素, 胰岛素类生长因子1, 糖尿病, 高血压

Abstract: 【Abstract】 Objective〓To evaluate the relationship of postoperative Insulin-like growth factor I (IGF-I).level with diabetes and hypertensions for growth hormone(GH)-secreting adenoma patients after transsphenoidal microsurgery. Methods〓Seventy-three patients harboring GH-secreting adenomas underwent transsphenoidal microsurgery were investigated retrospectively..Biochemical remission was defined as a normal age- and gender-matched IGF-I level. Among them, 21 cases were diabetes and 15 cases were hypertensions..Results〓Eleven cases got clinical symptomatic relief in diabetes among 15 cases with normal IGF-I level,and one case was clinical symptomatic relief among 6 cases with abnormal IGF-I level(P<0.05)..Six cases were hypertension clinical symptomatic relief among 10 cases with normal IGF-I level,.and one case was hypertension clinical symptomatic relief among 5 cases with abnormal IGF-I level..Conclusion〓Normal postoperative IGF-I level could moderate diabetes and hyperten-sion clinical symptoms for acromegalic patients with GH-secreting adenomas.

Key words: Growth hormone-secreting adenomas, Growth hormone, Insulin like growth factor I (IGF-I), Diabetes, Hypertension