恶性肿瘤外周神经转移研究进展

doi:10.3969/j.issn.1009-976X.2014.02.028

摘要/Abstract

摘要： 【摘要】〓外周神经浸润(PNI)与多种类型肿瘤转移、复发关系密切,是独立预后不良因素。本文从明确PNI概念开始,综述目前PNI分子和病理机制、体外内模型建立等研究进展,旨在更深入地了解PNI在肿瘤转移、复发中的作用,为进一步研究PNI机制及开发靶向PNI治疗策略奠定基础。

关键词: 外周神经浸润, 胰腺癌, 前列腺癌

Abstract: 【Abstract】〓Perineural invasion (PNI) has been reported to be closely related to the metastasis and recurrence in various cancers..For many of these malignancies,.PNI is emerging as an independent risk factor for poor prognosis. In the present study, a clear definition of PNI was laid out, and then the authors summarized current theories on the molecular mechanism and pathogenesis of PNI. In addition, current research in vitro and in vivo models for PNI were also introduced. The objectives of this review were to highlight the PNI status in predicting cancer metastasis and recurrence, as well as lead to advancements in the understanding and target therapy of this pathological entity.

Key words: Perineural invasion, Pancreatic cancer, Prostate cancer

中图分类号:

R735
R657.5

郭宇波曾林涓苏红黄开红. 恶性肿瘤外周神经转移研究进展[J]. 岭南现代临床外科, 2014, 14(02): 211-213.

Guo Yubo, Zeng Linjuan, Su Hong, Huang Kaihong. Research advances in the peripheral nerve metastasis of malignant tumors[J]. Lingnan Modern Clinics in Surgery, 2014, 14(02): 211-213.

参考文献

[1]Soo K C, Carter R L, O'Brien C J, et al.Prognostic implications of perineural spread in squamous carcinomas of the head and neck[J].Laryngoscope, 1986, 96(10):1145-1148
[2]Chinn S B, Spector M E, Bellile E L, et al.Impact of perineural invasion in the pathologically N0 neck in oral cavity squamous cell carcinoma[J].Otolaryngol Head Neck Surg, 2013, 149(6):893-899
[3]Fromont G, Godet J, Pires C, et al.Biological significance of perineural invasion (PNI) in prostate cancer[J].Prostate, 2012, 72(5):542-548
[4]Lee J T, Lee S, Yun C J, et al.Prediction of perineural invasion and its prognostic value in patients with prostate cance r[J].Korean J Urol, 2010, 51(11):745-751
[5]Cozzi G, Rocco B M, Grasso A, et al.Perineural invasion as a predictor of extraprostatic extension of prostate cancer: a systematic review and meta-analysis[J].Scand J Urol, 2013, 47(6):443-448
[6]Demir I E, Ceyhan G O, Liebl F, et al.Neural invasion in pancreatic cancer: the past,present and future[J].Cancers (Basel), 2010, 2(3):1513-1527
[7]Imoto A, Mitsunaga S, Inagaki M, et al.Neural invasion induces cachexia via astrocytic activation of neural route in pancreatic cancer[J].Int J Cancer, 2012, 131(12):2795-2807
[8]Sahin I H, Shama M A, Tanaka M, et al.Association of diabetes and perineural invasion in pancreatic cancer[J].Cancer Med, 2012, 1(3):357-362
[9]Ueno H, Shirouzu K, Eishi Y, et al.Characterization of perineural invasion as a component of colorectal cancer staging[J].Am J Surg Pathol, 2013, 37(10):1542-1549
[10]Huh J W, Lee J H, Kim H R, et al.Prognostic significance of lymphovascular or perineural invasion in patients with locally advanced colorectal cancer[J].Am J Surg, 2013, 206(5):758-763
[11]Kawamata H, Yamashita K, Nakamura K, et al.Perineural invasion and preoperative serum CA19-9 as predictors of survival in biliary tract cancer[J].Anticancer Res, 2013, 33(2):583-594
[12] Kim H J, Kim C Y, Hur Y H, et al.The prognostic factors for survival after curative resection of distal cholangiocarcinoma: perineural invasion and lymphovascular invasion[J].Surg Today, 2014, :-
[13]Batsakis J G.Nerves and neurotropic carcinomas[J].Ann Otol Rhinol Laryngol, 1985, 94(4 Pt 1):426-427
[14]Kameda K, Shimada H, Ishikawa T, et al.Expression of highly polysialylated neural cell adhesion molecule in pancreatic cancer neural invasive lesion[J].Cancer Lett, 1999, 137(2):201-207
[15]Liebig C, Ayala G, Wilks J A, et al.Perineural invasion in cancer: a review of the literature[J].Cancer, 2009, 115(15):3379-3391
[16]Ayala G E, Wheeler T M, Shine H D, et al.In vitro dorsal root ganglia and human prostate cell line interaction: redefining perineural invasion in prostate cancer[J].Prostate, 2001, 49(3):213-223
[17]Cornell R J, Rowley D, Wheeler T, et al.Neuroepithelial interactions in prostate cancer are enhanced in the presence ofprostatic stroma[J].Urology, 2003, 61(4):870-875
[18]Ding Y, He D, Florentin D, et al.Semaphorin 4F as a critical regulator of neuroepithelial interactions and a biomarker of aggressive prostate cancer[J].Clin Cancer Res, 2013, 19(22):6101-6111
[19]Cavel O, Shomron O, Shabtay A, et al.Endoneurial macrophages induce perineural invasion of pancreatic cancer cells by secretion of GDNF and activation of RET tyrosine kinase receptor[J].Cancer Res, 2012, 72(22):5733-5743
[20]Magnon C, Hall S J, Lin J, et al.Autonomic nerve development contributes to prostate cancer progression[J].Science, 2013, 341(6142):1236361-
[21]Boyd J G, Gordon T.Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury[J].Mol Neurobiol, 2003, 27(3):277-324
[22]Chen H, Yuan Y, Zhang C, et al.Involvement of S100A14 protein in cell invasion by affecting expression and function of matrix metalloproteinase (MMP)-2 via p53-dependent transcriptional regulation[J].J Biol Chem, 2012, 287(21):17109-17119
[23]Botta G P, Reginato M J, Reichert M, et al.Constitutive K-RasG12D activation of ERK2 specifically regulates 3D invasion of human pancreatic cancer cells via MMP-1[J].Mol Cancer Res, 2012, 10(2):183-196
[24]Abiatari I, Deoliveira T, Kerkadze V, et al.Consensus transcriptome signature of perineural invasion in pancreatic carcinoma[J].Mol Cancer Ther, 2009, 8(6):1494-1504
[25]Albini A.Tumor and endothelial cell invasion of basement membranesThe matrigel chemoinvasion assay as a tool for dissecting molecular mechanisms[J].Pathol Oncol Res, 1998, 4(3):230-241
[26]Miknyoczki S J, Lang D, Huang L, et al.Neurotrophins and Trk receptors in human pancreatic ductal adenocarcinoma: expression patterns and effects on in vitro invasive behavior[J].Int J Cancer, 1999, 81(3):417-427
[27]Djakiew D, Pflug B R, Delsite R, et al.Chemotaxis and chemokinesis of human prostate tumor cell lines in response to human prostate stromal cell secretory proteins containing a nerve growth factor-like protein[J].Cancer Res, 1993, 53(6):1416-1420
[28]Pour P M, Egami H, Takiyama Y.Patterns of growth and metastases of induced pancreatic cancer in relation to the prognosis and its clinical implications[J].Gastroenterology, 1991, 100(2):529-536
[29]Bosland M C, Prinsen M K, Dirksen T J, et al.Characterization of adenocarcinomas of the dorsolateral prostate induced in Wistar rats by N-methyl-N-nitrosourea,7,12-dimethylbenz(a)anthracene,and 3,2'-dimethyl-4-aminobiphenyl,following sequential treatment with cyproterone acetate and testosterone propionate[J].Cancer Res, 1990, 50(3):700-709
[30]Hingorani S R, Petricoin E F, Maitra A, et al.Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse[J].Cancer Cell, 2003, 4(6):437-450
[31]Koide N, Yamada T, Shibata R, et al.Establishment of perineural invasion models and analysis of gene expression revealed an invariant chain (CD74) as a possible molecule involved in perineural invasion in pancreatic cancer[J].Clin Cancer Res, 2006, 12(8):2419-2426
[32]Pour P M, Egami H, Takiyama Y.Patterns of growth and metastases of induced pancreatic cancer in relation to the prognosis and its clinical implications[J].Gastroenterology, 1991, 100(2):529-536
[33]Eibl G, Reber H A.A xenograft nude mouse model for perineural invasion and recurrence in pancreatic cancer[J].Pancreas, 2005, 31(3):258-262
[34]Adriaenssens E, Vanhecke E, Saule P, et al.Nerve growth factor is a potential therapeutic target in breast cancer[J].Cancer Res, 2008, 68(2):346-351