关键词: 氯胺酮相关性膀胱炎, 地塞米松, 利多卡因

Abstract: 【Abstract】 Objective To observe the treatment efficacy of of ketamine-related cystitis by vesicoclysis with dexamethasone and alkalinized lidocaine. Methods Eight male patients with ketamine-related cystitis,.who failed to routine treatment with withdrawal ketamine,.antibiotics,.tolterodine, alfuzosin,.were enrolled in this study..The patients were treated by regular vesicoclysis with dexamethasone and alkalinized lidocaine for 6 weeks,.then recorded the therapeutic effect by voiding diary and OABSS.in 1-3 weeks after stopping treatment. Results Eight patients made significant improvement after 6 weeks treatment..The frequency of daytime and nocturia micturition decreased from 20.5±7.8 to 5.6±2.3 and from 15.5±3.2 to 3±1.2 respectively (P<0.05), the urine volume increased from 30.4±12.4 mL to 50±10.1 mL (P<0.05), the OABSS decreased from 10.7±1.5 to 5.2±1.3.(P<0.05). All the patients had no adverse drug reactions. Conclusion The treatment of ketamine-related cystitis by vesicoclysis with dexamethasone and alkalinized lidocaine proved safe and feasible in a short term,.and the drugs are popular and low-cost..So it is advised to use for patients who refuse surgical treatment.

Key words: Dexamethasone, Lidocaine, Ketamine, Cystitis