关键词: 结肠癌, 免疫组织化学, 环氧水解酶类, 生存素

Abstract: 【Abstract】 Objective To investigate the expression correlation of survivin and cyclooxygenase-2 (COX-2) in normal colon tissue, colonic adenomas and colon cancer. Methods In order to establish the role of survivin and COX-2 in colon cancer development,we studied the expression of survivin and COX-2 in 46 cases of normal colon mucosa,58 cases of colonic adenomas and 34 cases of colon cancer by using immunohistochemical techniques using EnVision system. Results No expression of survivin and COX-2 was found in normal colonic mucosa. However, colonic adenomas and colon tumors exhibited a high degree of survivin and COX-2 expression,.especially in colon cancer tissue. Conclusions The high expression of survivin and COX-2 is integrally associated with the process of colon carcinogenesis. There may be a common activation mechanism between survivin and COX-2 expressions.

Key words: Colon cancer, Immunohistochemistry, Epoxide Hydrolase, Survivin