关键词: 连续性血液净化, 细胞因子, 炎症介质, 重症急性胰腺炎

Abstract: 【Abstract】 Objective To explore the effect of continuous blood purification.(CBP).for eliminating plasma inflammatory mediators in patients with severe acute pancreatitis (SAP). Methods Thirty -six patients with SAP were treated by CBP..Four plasma cytokines including TNF -α,.IL -1β,.IL -6,.IL -8 were detected by ELISA at 0,.24,.48 hours after CBP. Results The levels of TNF -α,.IL -1β,.IL -6,IL -8 were significantly higher than that of control group..Thirty -one of all patients got rehabilitation after CBP with a high survival rate.(86.1%).and significant improvement of serum biochemical indexes..The plasma level of cytokines declined at 24 hours after CBP.(P<0.05).and these indexes had rebound in different degree at 48 hours after CBP but were still lower than that before CBP..Conclusion CBP effectively clears the plasma inflammatory mediators,.therefore blocks systemic inflammatory response and improves the prognosis of SAP.

Key words: Continuous blood purification, Cytokine, Inflammatory mediator, Severe acute pancreatitis