关键词: LAP⁺CD4⁺T细胞, 调节性T细胞, 转化生长因子-β

Abstract:

【Abstract】 Having a suppressive effect on immune response, regulatory T cells (Tregs) play an important role in the maintenance of homeostasis. Treg cells are necessary both to maintain self-tolerance and prevent the onset of autoimmune disease. The Treg cells studied previously were mainly divided into three subpopulations: CD4+CD25+T cells, Th3 cells and Tr1 cells. These T cells exert the immune suppressive function by producing some kinds of cytokines, such as IL-10 and TGF-β, with the ability of immune suppressive. Recently, LAP+CD4+T cells have been identified as a new subset of Treg cells and a population with regulatory function both in vitro and in vivo. This regulatory function is partly mediated by TGF-β and IL-10. In animal experiments, these cells have been shown to affect the genesis and development of some diseases, such as autoimmune disorder and inflammatory disease. A few researches implied that these cells also play an important role in tumor progression in patients with cancer.

Key words: LAP+CD4+T cells, Regulatory T cells, Transforming growth factor-β