CD4+CD25+Foxp3+T调节淋巴细胞与乳腺癌

摘要/Abstract

摘要： 调节性T细胞（Regulatory T cell，Treg），之前被称为抑制性T细胞(Ts)，它在维持机体的自身免疫耐受方面发挥着重要的作用，可对宿主免疫系统产生抑制作用，使荷瘤宿主内一定数量的效应性细胞功能被抑制，以此给肿瘤提供逃避免疫识别和杀伤的机会。既往大量实验已证实了免疫调节细胞的存在，特别是调节性T细胞亚群[1]。Mukherji 等在1986年从黑素瘤患者淋巴结组织中鉴定出Treg细胞, 这是人类首次在肿瘤组织中发现Treg细胞。Sakaguchi及其同事在1995年证明 CD25, 即 IL-2受体的 α 链,在鼠 CD4+T 细胞亚群中持续表达, 这些细胞在体内外都具有较强的免疫抑制活性[2]。随后体外研究发现Foxp3（叉头状／翼状螺旋转录因子3，forkhead／wingedhelixtranscriptionfactor 3）转录因子对Treg 细胞的发育起决定性作用 ,并且Foxp3 的表达是 Treg 细胞的特殊性标记[3]。这些研究成果让有关Treg的研究得到快速发展。本文就Treg细胞与乳腺癌的关系作一综述。

中图分类号:

R543

余海云李文萍王颀. CD4+CD25+Foxp3+T调节淋巴细胞与乳腺癌[J]. 岭南现代临床外科, 2011, 11(04): 284-288.

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