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岭南现代临床外科 ›› 2011, Vol. 11 ›› Issue (01): 5-8.

• 论著 • 上一篇    下一篇

110例壶腹周围癌胰十二指肠切除术后预后分析

王俊1,李升平2,林国和3,李书红3,张金野3   

  1. 1. 中山大学肿瘤防治中心室
    2. 中山大学肿瘤防治中心,华南肿瘤学国家重点实验室
    3. 中山大学肿瘤防治中心
  • 通讯作者: 李升平

Prognositic analysis of pancreaticoduodenectomy in 110 patients with periampullary carcinoma

  • Received:2010-11-23 Revised:2011-01-13 Online:2011-02-20 Published:2011-03-08

摘要: 目的:探讨壶腹周围癌中不同类型肿瘤的临床病理特征及与手术、预后的关系。方法:回顾性分析行胰十二指肠切除术的110例壶腹周围癌临床病理及生存时间。结果:全组包括胰头癌60例(54.5%),胆总管下端癌19例(17.3%), Vater壶腹部癌24例(21.8%)和十二指肠乳头癌7例(6.4%);胰腺癌组与非胰腺癌组患者在手术时间、术中出血量、切缘阳性率及淋巴结转移阳性率之间差异有统计学意义,肿瘤分期、阳性切缘及淋巴结转移均是影响患者Whipple术后生存率的独立危险因素;胰腺癌患者与非胰腺癌患者Whipple术后5年生存率差异有统计学意义(P<0.05)。结论:肿瘤分期与阳性切缘、淋巴结转移是影响Whipple术后生存的独立危险因素,非胰腺癌较胰腺癌术后预后更好。

关键词: 壶腹周围癌, 胰十二指肠切除术, 预后, Periampullary carcinoma, pancreaticoduodenectomy, prognosis

Abstract: Objective: Analyse clinical pathological characteristics in different tumor of periampullary and its correlation with clinical prognosis. Methods: Retrospective review of clinicopathological and follow-up data in 110 patients with pancreaticoduodenectomy sufferring from periampulary cancer. Results:The operative time ,blood loss ,positive rate in surgical margin and lymph node metastsis is significant high in pancreatic caner group than non-pancreatic cancer group.Tumor stage,positive surgical margine and lymph node metastasis is significant independent risk factors for patients with pancreaticoduodenectomy.There was significant difference in pancreatic carcinoma and non-pancreatic carcinoma with pancreaticoduodenectomy. Conclusion:Tumor stage,positive surgical margine and lymph node metastasis is significant independent risk factors for patients with pancreaticoduodenectomy.Prognosis of non-pancreatic carcinoma was better than pancreatic carcinoma with pancreaticoduodenectomy