关键词: 乌司他丁, 老年患者, 急腹症, 肿瘤坏死因子- a, 白细胞介素-6

Abstract: [Abstrcat]: Objective: To investigate the effects of different-dose ulinastatin(UTI) on tumor necrosis factor-alpha (TNF-a) and interleukin-6(IL-6) of old surgical abdomen patients in surrounding operation time. Method: 120 old surgical abdomen patients were randomly divided into 4 groups(n=30)：the blank control group, UTI 5000U／kg，10，000U／kg and 20，000U／kg． The blood from central vein was gained at various time points． TNF-a and IL-6 in every blood sample were determined．Observe the therapeutic in each group. Result: TNF-a and IL-6 in every treatment group were obviously lower than which in blank control group (p<0.05); TNF-a and IL-6 in every treatment group at the same time points decreased progressively compared with U1(UTI 5000U／kg) (p<0.05). The incidence rate of multiple organ dysfunction syndrome(MODS) was no significant difference between U1(UTI 5000U／kg) and blank control group（P > 0. 05），and which in U2( UTI 10，000U／kg)and U3(20，000U／kg ) were obviously lower than which in blank control group (p<0.05);The case fatality rate in each treat group was no significant difference compared with which in blank group（P > 0. 05）. Conclusion: UTI shows dose-dependent effect inhibiting the delivery of cytokine such as TNF-a and IL-6,and obviously lessen the systemic inflammatory reaction syndrome(SIRS),and obstruct multiple organ dysfunction syndrome(MODS),which conduces to help the sufferer to pass the surrounding operation time.