关键词: 乳腺癌, 化疗, 口腔黏膜炎, 冷盐水, Breast cancer, Chemotherapy, Stomatitis, Cold saline

Abstract: Objective To observe of the preventive effect of the cold saline gargling to chemotherapy- induced stomatitis for patients with breast cancer. Methods 157 patients with breast cancer chemotherapy were randomly divided into groups A, B, C .In group A, after the start of chemotherapy, 53 cases gargled with cold saline. In group B, after the start of the chemotherapy,50 cases gargled with xinzuo gargle.In group C, 54 cases had no additional other treatment. All patients were observed after one week for incidence and composition of stomatitis. Results The incidence of stomatitis in groupA, B, C were 5.66%, 18.0%, 25.93% respectively. The comparision between groupA and group B:?2=3.85,p<0.05, the comparision between group B and group C: ?2=1.95,p>0.05, and the comparision between group A and group C: ?2=8.22,p<0.01. Conclusion Cold saline gargling would more effectively prevent the occurrence of stomatitis.