关键词: 肝癌, 生长抑素, MMP-2, TIMP-2, hepatocellular carcinoma, somatostatin , MMP-2 , TIMP-2

Abstract: Objective To observe concentration changes and intervention of somatostatin of MMP-2 and TIMP-2 of plasma after hepatectomy in patients with liver cancer. Methods Twenty cases received hepatectomy were randomly divided into teo groups namely conventional therapeutic group and somatostatin treatment group. Ten cases were in each group. The somatostatin was given in the somatostatin treatment group. Results The plasma concentration of MMP-2 was significantly increased and The plasma concentration of TIMP-2 was significantly decreased after hepatectomy. The administration of somatostatin could decrease the plasma concentration of MMP-2 and increase the plasma concentration of MMP-2. Conclusions The administration of somatostatin after hepatectomy might suppress of recurrence after surgery.