关键词: NF-кB, MUC1, 胆管结石, 胆管癌, NF-кB, MUC1, lithiasis, cholangiocarcinoma

Abstract: Objective To investigate the expression and significance of NF-кB and MUC1 in hepatolithiasis associated with intrahepatic cholangiocarcinoma. Methods Ninety cases of liver tissues specimen of hepatectomy were selected in The Second Affiliated Hospital of Sun Yat-sen University in recent 20 years. Among them, 33 cases with hepatolithiasis associated with intrahepatic cholangiocarcinoma were as experiment group, 32 cases with hepatolithiasis were as control group and 25 cases with normal intrahepatic duct tissues were an blank group. The immunohistochemical staining of NF-кB and MUC1 were performed by tissues slice.Results 1)There was significant difference in NF-кB and MUC1 positive expression rate (P＜0.05).2)MUC1 positive expression rate showed significant difference in histopathologic grading and in lymph node metastasis (P＜0.01,0.05).3)Accumulated survival rate of MUC1 expressed tumor patients was lower than that of MUC1 non-expressed tumor patients(P＜0.01). Conclusion NF-кB expression is probably the early stage in the carcinogenesis of intrahepatic cholangiocarcinoma and in the formation of hepatolithiasis. High level expression of MUC1 is related with malignan degree of cholangiocarcinoma and with worse prognosis.