关键词: 艾沙康唑, 毛孢子菌, 肝衰竭, 肝移植

Abstract: Objective To explore the feasibility of isavuconazole in the treatment of Trichosporon infection and share clinical experience. Methods Through a retrospective analysis of the treatment process of two cases of pneumonia caused by Trichosporon during the perioperative period of liver transplantation at our hospital, combined with the study of relevant literature, we summarize the characteristics and treatment points of trichosporonosis, as well as the evaluate the feasibility of using isavuconazole to treat trichosporonosis. Results Two patients underwent liver transplantation for “liver failure,” and the lung trichosporonosiswas detected earlier through metagenomic next-generation sequencing technology before the operation. After treatment with amphotericin B failed, two patients were treated with isavuconazole in combination. Case 1 was also complicated with pulmonary Aspergillus fumigatus infection after surgery. The treatment of isavuconazolefor nearly 10 months showed improvement in both pulmonary lesions on imaging and negative results of fungal etiology for many times. Case 2 was treated with isavuconazole for 2 weeks and finally cured. As of the submission date, case 1 patient had died and Case 2 patient was still alive. Conclusion Isavuconazole is a potentially effective drug for trichosporonosis.

Key words: isavuconazole, trichosporon, liver failure, liver transplantation