关键词: 代谢综合征, 非三阴型乳腺癌, 预后

Abstract: Objective To explore the prognostic value of metabolic syndrome （MS） and its components in outcome of patients with non-Triple Negative Breast Cancer（non-TNBC）. Methods The study included the newly diagnosed non-TNBC during Jan 1 2016 and Mar 30 2017. Clinical and pathological data were collected, and the patients were followed up for 3 years. The Kaplan-Meier analysis was used to explore the association between the MS and its components and the overall survival （OS）. The prognosis factors were analyzed by the multivariable Cox proportional hazards regression models. Results 194 patients were included with 12 in MS group and 168 in non-MS group. During the follow-up, there were 2 patients died in MS group, which OS rate was 81.8%. While in the non-MS group, 2 patients died and the OS rate was 98.8% （P<0.05）. After adjusting the menopausal status age, tumor stage and pathological factors, MS was the independently risk factor for poor OS （HR=62.788, 95%CI：1.342-2937.323, P<0.05）. The patients with two or more items of hypertension, hyperglycemia and dyslipidemia had higher death risk, compared with the patient with only one or none of them （HR=23.397, 95%CI：1.918-285.405, P<0.05）. Conclusion MS was associated with poor prognosis of non-Triple Negative Breast Cancer.

Key words: metabolic syndrome, non-triple negative breast cancer, prognosis