关键词: 牙源性肿瘤, 牙源性粘液纤维瘤, 牙源性粘液瘤, 诊断

Abstract: Objective To investigate the clinicopathological features and diagnosis of myxoifibroma of jaw bone. Methods We collected 7 cases of maxillary myxoifibroma from July 2018 to March 2022 in the Department of Pathology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University. The clinical data, imaging, morphology, immunohistochemical results and treatments of the patients were analyzed. Results There were 3 males and 4 females in 7 cases of maxillary myxoifibroma, aged from 5 to 50 years old, with a median age of 36 years and an average age of 29.286±18.382 years. All patients underwent surgical treatment. Both imaging and microscopy showed bone destruction. The tumor showed a loose mesh structure, matrix myxedema. Spindle or star-axed tumor cells were few and scattered, with oval nuclei and rare nuclear mitosis. Vimentin was consistently expressed in tumor cells （4/4） and Actin was expressed in some cases （2/5）, while Desmin, S-100, CD34 and β-catenin were totally negative. Ki67 positive index was 2% ~ 5%. Conclusion Maxillary myxoifibroma is a rare and benign otogenic tumor, but it is locally invasive and has a high recurrence rate, requiring follow-up. Preoperative imaging is tend to be confused with other jaw tumors, and histopathological and immunohistochemical inspections are required to confirm the diagnosis. Surgical excision is the main treatment method at present.

Key words: odontogenic tumor, odontogenic myxofibroma, odontogenic myxoma, diagnosis