关键词: 脑梗死, 孤立性远端深静脉血栓, 肺栓塞, 影响因素分析

Abstract: Objective To explore the risk factors for the progression of acute cerebral infarction combined with isolated distal deep vein thrombosis （IDDVT） to pulmonary embolism during hospitalization Methods Patients with acute cerebral infarction combined with IDDVT who were admitted to the Traditional Chinese Medical Hospital of Zhongshan from January 2019 to December 2021 were enrolled. The case data and outcome information were collected, and the risk factors for the progression of IDDVT to pulmonary embolism were analyzed. Results A total of 141 patients were included in the study. The length of hospital stay was 6-64 （21.9±10.1） days, 2 patients （1.4%） developed into proximal deep vein thrombosis （PDVT）. Thirteen patients （9.2%） developed into pulmonary embolism, of which 1 case was high-risk pulmonary embolism, and 12 were low-risk pulmonary embolism. Univariate analysis and multivariate logistic regression analysis showed that the length of hospital stay （OR=1.036, 95%CI： 1.034~1.164, P=0.002）, thrombosis involving bilateral lower extremities （OR=6.163, 95%CI： 1.269~29.931, P=0.024）, increased D-dimer （OR=1.122, 95%CI： 1.020-1.233, P=0.017） were independent risk factors of acute cerebral infarction combined with IDDVT developing into pulmonary embolism. Conclusion The incidence of acute cerebral infarction combined with IDDVT developing into PDVT during hospitalization is low, and the incidence of developing into pulmonary embolism is high, which may lead to high-risk pulmonary embolism. Length of hospital stay, thrombosis involving bilateral lower extremities, and increased D-dimer are independent risk factors of acute cerebral infarction combined with IDDVT developing into pulmonary embolism

Key words: cerebral infarction, isolated distal deep vein thrombosis, pulmonary embolism, influence factor analysis