FDX1在胶质瘤中的表达及其预后意义

doi:10.3969/j.issn.1009-976X.2022.05.014

岭南现代临床外科 ›› 2022, Vol. 22 ›› Issue (05): 509-511.DOI: 10.3969/j.issn.1009-976X.2022.05.014

FDX1在胶质瘤中的表达及其预后意义

张博弘^1,2, 谢琳³, 欧阳乐平³, 何明亮^3,*

1.中山大学附属第七医院科研中心;2.麻醉科,深圳 518107;
3.中山大学孙逸仙纪念医院神经外科,广州 510120

通讯作者: *何明亮,Email：hemliang3@mail.sysu.edu.cn

The expression and prognostic significance of FDX1 in glioma

ZHANG Bo-hong^1,2, XIE Lin³, OUYANG Le-ping³, HE Ming-liang³

1. Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China;
2. Department of Anesthesiology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China;
3. Department of Neurosurgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China

Received:2022-08-20 Online:2022-10-20 Published:2022-12-06
Contact: HE Ming-liang, hemliang3@mail.sysu.edu.cn

摘要/Abstract

摘要： 目的探讨铁氧还原蛋白1（FDX1）在胶质瘤中的表达水平和预后意义。方法采用免疫组织化学法检测我院神经外科40例恶性胶质瘤样本和20例外伤性脑组织样本中FDX1的表达水平,分析其与患者临床病理因素和预后的关系。结果 FDX1在恶性胶质瘤组织中的蛋白表达水平显著高于外伤性脑组织（P<0.01）;FDX1的表达与恶性胶质瘤病理分级呈正相关（P<0.01）;Kaplan-Meier生存分析显示FDX1高表达组患者总生存率显著低于低表达组患者（P<0.01）。Cox多因素回归模型显示FDX1表达强度（相对危险度为2.003,P<0.01）和肿瘤分级（相对危险度为2.279,P<0.01）是恶性胶质瘤患者预后的独立危险因素。结论 FDX1高表达与恶性胶质瘤的发生发展有关,对患者总体生存时间有显著影响,可能是胶质瘤患者预后不良的重要指标。

关键词: FDX1, 胶质瘤, 预后

Abstract: Objective To investigate the expression and clinical significance of FDX1 in malignant glioma. Methods Immunohistochemical method was used to detect the expression of FDX1 in 40 glioma samples and 20 traumatic brain samples. The relationship between the expression of FDX1 and clinicopathological factors was analyzed. Kaplan-Meier methodwas used for survival analysis. Results The expression of FDX1 in glioma samples was significantly higher than that in non-neoplastic brain samples （P<; 0.01）. The expression of FDX1 was positively related with pathology classification of glioma （P<; 0.01）. Kaplan-Meier curve showed that the overall survival rate of patients in the high expression group of FDX1 was significantly lowerthan that in the low expression group （P<; 0.01）. By multivariate Cox analysis, FDX1 and classification were identified as the independent predictive factors. Conclusion FDX1 may play an important role in the occurrence and development of glioma, and may serve as a biomarker of poor prognosis.

Key words: FDX1, glioma, prognosis

中图分类号:

R739.41

张博弘, 谢琳, 欧阳乐平, 何明亮. FDX1在胶质瘤中的表达及其预后意义[J]. 岭南现代临床外科, 2022, 22(05): 509-511.

ZHANG Bo-hong, XIE Lin, OUYANG Le-ping, HE Ming-liang. The expression and prognostic significance of FDX1 in glioma[J]. Lingnan Modern Clinics In Surgery, 2022, 22(05): 509-511.

参考文献

[1] Ostrom QT, Gittleman H, Fulop J, et al. CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in2008-2012[J]. Neuro Oncol, 2015, 17(Suppl 4): iv1-iv62.
[2] Tsvetkov P, Coy S, Petrova B, et al.Copper induces cell death by targeting lipoylated TCA cycle proteins[J]. Science, 2022, 375(6586): 1254-1261.
[3] Sheftel AD, Stehling O, Pierik AJ, et al.Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis[J]. Proc Natl Acad Sci USA, 2010, 107(26): 11775-11780.
[4] Xiao C, Yang L, Jin L, et al.Prognostic and immunological role of cuproptosis-related protein FDX1 in pan-cancer[J]. Front Genet, 2022, 13: 962028.
[5] Zhang C, Zeng Y, Guo X, et al.Pan-cancer analyses confirmed the cuproptosis-related gene FDX1 as an immunotherapy predictor and prognostic biomarker[J]. Front Genet, 2022, 13: 923737.
[6] Zhang WT, Gong YM, Zhang CY, et al.A Novel Cuprotosis-Related Gene FDX1 Signature for Overall Survival Prediction in Clear Cell Renal Cell Carcinoma Patients[J]. Biomed Res Int, 2022, 2022: 9196540.
[7] Zhang Z, Ma Y, Guo X, et al.FDX1 can Impact the Prognosis and Mediate the Metabolism of Lung Adenocarcinoma[J]. Front Pharmacol, 2021, 12: 749134.
[8] Zhang Z, Zeng X, Wu Y, et al.Cuproptosis-Related Risk Score Predicts Prognosis and Characterizes the Tumor Microenvironment in Hepatocellular Carcinoma[J]. Front Immunol, 2022, 13: 925618.
[9] Bruni D, Angell HK, Galon J.The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy[J]. Nat Rev Cancer, 2020, 20(11): 662-680.
[10] Hinshaw DC, Shevde LA.The Tumor Microenvironment Innately Modulates Cancer Progression[J]. Cancer Res, 2019, 79(18): 4557-4566.
[11] La Vecchia S, Sebastián C.Metabolic pathways regulating colorectal cancer initiation and progression[J]. Semin Cell Dev Biol, 2020, 98: 63-70.

[1]	叶臻, 林㼆. PARP1表达在预测结直肠癌总体生存中的作用[J]. 岭南现代临床外科, 2022, 22(05): 466-474.
[2]	张桥, 莫阿里, 高恒毅, 周伟, 夏丰, 张伟桥, 陈伟强. 直径不大于5 cm孤立性肝癌：射频消融与手术治疗的比较[J]. 岭南现代临床外科, 2022, 22(04): 328-335.
[3]	周华彬, 高志光, 郑超, 张涛, 刘玉兰, 利民. 基于SEER数据库的T1M1期结直肠癌临床病理特征及预后分析[J]. 岭南现代临床外科, 2022, 22(03): 227-231.
[4]	顾杨, 刘勋, 区绮云, 张娜, 李涵, 秦伟强, 李莉. 基于深度学习算法的免疫细胞丰度模型预测脓毒症患者的生存预后[J]. 岭南现代临床外科, 2022, 22(02): 154-162.
[5]	何冲, 周姝睿, 李雅晴, 陈少杰, 练国达, 陈尚祥, 黄开红. 胰腺癌预后相关铁死亡基因筛选及预后预测模型构建[J]. 岭南现代临床外科, 2022, 22(01): 14-23.
[6]	刘伟. 恶性脑胶质瘤单放和放化疗临床疗效5年随诊分析[J]. 岭南现代临床外科, 2022, 22(01): 89-93.
[7]	胡明超, 朱宝松. NDC1基因在结肠癌中诊断及预后价值的生物信息学分析：一项基于TCGA数据库的研究[J]. 岭南现代临床外科, 2021, 21(06): 598-602.
[8]	宋燕州, 康志龙, 苏一男, 张毅明, 赵新, 李志伟, 李伟. NEK7在原发性肝细胞肝癌患者中表达及其临床意义[J]. 岭南现代临床外科, 2021, 21(06): 608-613.
[9]	王道笃, 赵其炯, 周志标, 何永越. 基于铁死亡相关基因构建肝细胞癌的预后模型[J]. 岭南现代临床外科, 2021, 21(04): 419-424.
[10]	黄欣瑶, 杨谢峰, 苏妍, 邢振. 磁共振扩散加权成像和灌注加权成像在非典型脑炎与低级别胶质瘤鉴别诊断中的价值[J]. 岭南现代临床外科, 2021, 21(04): 437-440.
[11]	王庆斌, 商昌珍, 陈亚进. 肝癌切除术后预后预测的研究进展[J]. 岭南现代临床外科, 2021, 21(04): 471-476.
[12]	朱钊雯, 贾卫娟, 刘洁琼. Luminal型乳腺癌胞膜蛋白相关预后模型的构建与验证[J]. 岭南现代临床外科, 2021, 21(03): 281-286.
[13]	曾兵, 李锦宏, 蔡灿锋, 辛海洋, 曾军. ITGAV在结直肠癌中的表达及临床意义[J]. 岭南现代临床外科, 2021, 21(03): 309-312.
[14]	伍隽华, 陈云扬, 张鑫, 余杰雄, 崔恩铭, 张慧玲. 肝癌患者中RNF24的表达及临床价值[J]. 岭南现代临床外科, 2021, 21(02): 165-170.
[15]	朱传华, 谢琳, 刘安民. PDIA4基因沉默对胶质瘤细胞凋亡的影响[J]. 岭南现代临床外科, 2021, 21(02): 177-181.

FDX1在胶质瘤中的表达及其预后意义

The expression and prognostic significance of FDX1 in glioma

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics