关键词: 基质金属蛋白酶11, 转化生长因子-β, 胸主动脉瘤, 相关性, 真性动脉瘤, 主动脉夹层动脉瘤

Abstract: Objective To explore the significance of serum matrix metalloproteinase 11 （MMP-11） and transforming growth factor-β （TGF-β1） levels in patients with thoracic aortic aneurysm. Methods Thirty patients with thoracic aortic aneurysm who were treated in the hospital between July 2020 and December 2020 were selected as the research subjects and included in study group, and another 30 healthy volunteers were selected as controls and enrolled as control group. The differences in the expression levels of serum MMP-11 and TGF-β1 at the initial examination were compared between the two groups, and the correlation between serum MMP-11 and serum TGF-β1 in patients with thoracic aortic aneurysm was analyzed by pearson correlation coefficient. The patients in the study group were divided into true aneurysm subgroup and aortic dissecting aneurysm subgroup, and the differences in serum MMP-11 and TGF-β1 were compared. Results The levels of serum MMP-11 and TGF-β1 in study group were significantly higher than those in control group （P<0.05）. The level of serum MMP-11 in patients with thoracic aortic aneurysm was positively correlated with the level of serum TGF-β1 （P<0.05）. Serum levels of MMP-11 and TGF-β1 were significantly higher in true aneurysm subgroup than those in aortic dissecting aneurysm subgroup （P<0.05）. Conclusion There was a close relationship between MMP-11 expression and TGF-β1 regulation in patients with thoracic aortic aneurysm. Understanding the expression of MMP and TGF may be helpful for clinical prevention and treatment of thoracic aortic aneurysm

Key words: matrix metalloproteinase 11, transforming growth factor-β, thoracic aortic aneurysm, correlation, true aneurysm, aortic dissecting aneurysm