关键词: 结直肠癌, T1M1期, 预后分析, SEER数据库

Abstract: Objective To investigate the clinicopathological features and prognosis influencing factors of patients with stage T1M1 colorectal cancer. Methods Patients with stage T1M1 colorectal cancer data in the SEER database from 2010 to 2015 were collected, the survival curve was plotted by Kaplan-Meier method, and the survival analysis was tested by Log-Rank and the Cox proportional risk regression model was used for prognosis multivariate analysis. Results A total of 524 patients with stage T1M1 colorectal cancer were included, with a median follow-up of 14 months, 443 patients died of coloretal cancer, and a median survival time of 12 months. Log-Rank test results showed that age, sex, primary site of tumor, degree of tissue differentiation, multiple metastasis, surgery, regional lymph node dissection, chemotherapy, CEA were closely related to cancer-specific survival in patients with stage T1M1 colorectal cancer （P<0.05）, COX multivariate analysis showed that age, primary tumor site, degree of tissue differentiation, surgery, chemotherapy, and multiple metastases were independent risk factors affecting the prognosis of patients with stage T1M1 colorectal cancer. Conclusion Patients with stge T1M1 colorectal cancer age ≥ 65 years， right half colon cancer， poor degree of tissue differentiation， multiple metastases， without surgery and chemotherapy have a shorter survival.

Key words: colorectal cancer, T1M1, prognosis analysis, SEER database