关键词: 医用胶, IL-6, TNF-α, 急性创面

Abstract: Objective To investigate whether the healing speed of acute skin avulsion wound in mice was different between medical glue and traditional dressing change. Methods Eighteen C57 mice were randomly divided into three groups to make acute skin avulsionwounds, six mice in each group, namely medical glue group, vaseline group, and control group. The dressing were changed every 2 days for a total of 10 days. On the 0 th, 2 th, 6 th and 10 th days, the condition of wound healing was observed, the expressions of inflammatory mediators IL-6 and TNF-α were detected by Western blotting and ELISA respectively. On the 10 th day, the expression of IL-6 and TNF-α were observed by immunohistochemistry. Results On the 2 th, 6 th and 10 th days,the healing speed of the glue group was the fastest, followed by the control group, and the vaseline group was the slowest. For the expressions quantity of the IL-6 and TNF-α by Westernblotting and ELISA, the glue group was the lowest, followed by the control group, and the vaseline group was the highest. On the 10 th day,for the expression levels of IL-6 and TNF-α byimmunohistochemistry, the glue group was the lowest, followed by the control group, and the vaseline group was the highest. Conclusion Compared with traditional dressing change, medical glue can reduce inflammatory mediatorsand accelerate the healing of acute skin avulsion wound.

Key words: medical glue, IL-6, TNF-α, acute wound