关键词: 年轻乳腺癌, SEER数据库, 预后因素

Abstract: Objective To investigate the clinicopathological characteristics and prognostic factors of breast cancer ≤35 years old. Methods 171,799 patients with breast cancer from the national cancer institute surveillance, epidemiology, and results database （SEER, 2004-2010） were divided into a young group （4157 patients） and a non-young group （167,642 patients） ≤35 years old or >35 years old, and the clinicopathological differences between the two groups were analyzed by using calcine assay. Breast cancer OS and USES the Kaplan Meier method to calculate the median survival time for survival analysis, use Log-Rank test, single factor analysis of the results of single factor analysis statistically significant factors in the COX proportional hazards regression model with multiple factors analysis, get the independent risk factors affecting the prognosis of patients with breast cancer and the prognosis of patients with breast young independent factors. Results Young group compared to the young group was statistically significant in the clinical pathologic factors include： 35 or > 35 years old or less, staging, histological grading, N staging, molecular classification, whether to buy health insurance, including age, stage, histological grade, N staging, molecular classification, whether to buy health insurance was anindependent factor influence breast cancer head. In KM survival analysis, log-rank test showed that statistically significant factors suggested that patients with breast cancer ≤35 years old had a worse prognosis than those with > and 35 years old. In patients with breast cancer ≤35 years old, staging, histological grading, N staging, molecular typing, and whether to purchase medical insurance were independent factors influencing the prognosis of breast cancer. Conclusion In breast cancer ≤35 years old, higher stage, higher histological grade, more lymph node metastasis, more triple negative breast cancer or HER2 positive breast cancer, and more patients did not buy medical insurance. Age ≤35 years is an independent risk factor affecting the prognosis of breast cancer patients. In patients with breast cancer ≤35 years old, staging, histological grade, N staging, molecular typing, and whether to purchase medical insurance were independent factors influencing the prognosis of breast cancer.

Key words: young breast cancer, SEER database, prognostic factors