支架植入术对颈动脉狭窄患者血管再通及神经生化标志物的影响

doi:10.3969/j.issn.1009-976X.2020.06.011

摘要/Abstract

摘要： 目的研究支架植入术对颈动脉狭窄患者血管再通及神经生化物的影响。方法选取2016年1月~2020年1月我院收治的61例颈动脉狭窄患者,将患者采用随机数字表法分为手术干预组（n=30）和对照组（n=31）,对照组接受内科常规颈动脉狭窄手术治疗;手术干预组接受支架植入术治疗。对比两组患者治疗前和治疗四周后神经生化物[中枢神经特异蛋白（S100β）、人脑髓鞘碱性蛋白（MBP）、神经元特异性烯醇化酶（NSE）]、氧化应激因子[超氧化物歧化酶（SOD）,丙二醛（MDA）]、及认知功能评估;对比两组患者治疗期间出现的不良反应;对比两组患者治疗3、6个月后血管通畅情况。结果治疗后,相比于对照组,手术干预组S100β、MBP、NSE显著更低（P<0.05）;治疗后,相比于对照组,手术干预组SOD显著更高,MDA显著更低（P<0.05）;治疗后,相比于对照组,手术干预组MOCA评分显著更高（P<0.05）。结论支架植入术能够明显改善患者神经生化物、氧化应激因子和认知功能,提高术后血管再通率,且安全性较高。

关键词: 血管再通, 氧化应激因子, 支架植入术, 颈动脉狭窄, 神经生化物

Abstract: Objective To study the effect of stent implantation on recanalization and nerve cell biochemical in patients with carotid artery stenosis. Methods A total of 61 patients with carotid artery stenosis admitted to our hospital from January 2016 to January 2020 were selected and numbered by visiting sequence. SPSS22.0 software was applied to generate a random number table, and patients were into surgical intervention group and control group, consisting of experimental group （n=30） and control group （n=31） by random number table. The control group received internal medicine surgery of routine carotid artery stenosis; the experimental group received stent implantation. The two groups of patients were compared before treatment and four weeks after treatment in terms of nerve cell biochemicals [central nervous system specific protein （S100β）, human brain myelin basic protein （MBP）, neuron specific enolase （NSE）], oxidative stress factor [superoxide dismutase （SOD）, malondialdehyde （MDA）], and cognitive function assessment. The adverse reactions of the two groups of patients during treatment and the vascular patency of the two groups of patients after 3 and 6 months of treatment were compared. Results After treatment, compared with the control group, S100β, MBP, NSE were significantly lower in the experimental group （P< 0.05）. After treatment, compared with the control group, the experimental group had significantly higher SOD and significantly lower MDA （P> 0.05）. After treatment, the MOCA score of the experimental group was significantly higher than that of the control group （P< 0.05）. Conclusion Stent implantation can significantly improve the neuronal biochemicals, oxidative stress factors and cognitive function in patients, increase the rate of postoperative vascular recanalization with high safety.

Key words: carotid artery stenosis, stent implantation, vascular recanalization, nerve biochemicals, oxidative stress factor

中图分类号:

R654.2

林茂晖, 詹梦熊, 郑霖飞, 刘盛泽. 支架植入术对颈动脉狭窄患者血管再通及神经生化标志物的影响[J]. 岭南现代临床外科, 2020, 20(06): 736-740.

LIN Mao-hui, ZHAN Meng-xiong, ZHENG Lin-fei, LIU Sheng-ze. Effect of stent implantation on recanalization and nerve biochemical in patients with carotid artery stenosis[J]. Lingnan Modern Clinics in Surgery, 2020, 20(06): 736-740.

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