关键词: 新生儿坏死性小肠结肠炎, 脑血氧饱和度, 肠道血氧饱和度, 近红外光谱

Abstract: Objective To determine the value of near infrared spectroscopy （NIRS） in the diagnosis of neonatal necrotizing enterocolitis （necrotizing enterocolitis） by measuring the blood oxygen saturation of intestine by near infrared spectroscopy （NIRS） and comparing with the position and volume of necrotic bowel in operation changes of cerebral oxygen saturation in children with neonecrotizing enterocolitis.Methods Thirty cases of neonatal non intestinal diseases were selected as control group, 27 cases of neonatal necrotizing enterocolitis were diagnosed and conservative treatment failed. The intestinal oxygen saturation, cerebral oxygen saturation and peripheral blood oxygen saturation of the upper abdomen, lower abdomen, left abdomen and right abdomen of the control group and the operation group were measured by near-infrared spectroscopy （cerebral oxygen saturation meter）. The intestinal necrosis site and the volume of necrotic bowel were recorded in the operation group. The data of the two groups were compared. The proportion of the lowest value of the four measurement sites in accordance with the site of intestinal necrosis during operation, and the relationship between the measured value of intestinal blood oxygen saturation and the volume of necrotic bowel were calculated in the operation group. T-test was used to compare the two groups. The degree of compliance before and after operation was used as percentage. The relationship between intestinal oxygen saturation and necrotic bowel volume was analyzed by Pearson correlation. Results There were significant differences in intestinal oxygen saturation, cerebral oxygen saturation and blood oxygen saturation between the same part of the control group and the operation group, P<0.05, with significant statistical difference. The lowest value of the four measurement sites in the operation group was 85.2% consistent with the necrotic site during operation, and there was a negative linear correlation between intestinal oxygen saturation and the volume of necrotic bowel. Conclusion Near infrared spectroscopy is an effective method to measure intestinal oxygen saturation and cerebral oxygen saturation, which has a certain evaluation value for the degree of intestinal necrosis, and has certain significance for the early diagnosis of neonatal necrotizing enterocolitis.

Key words: near infrared spectroscopy, cerebral oxygen saturation, intestinaloxygen saturation, neonatal necrotizing enterocolitis