二氢杨梅素的抗肿瘤机制研究进展

doi:10.3969/j.issn.1009-976X.2020.03.032

摘要/Abstract

摘要： 二氢杨梅素（Dihydromyricetin,DHM）是从葡萄科植物—藤茶茎叶部中提取出来的多酚羟基双氢黄酮醇类化合物。当代药理学已有的研究表明其抗肿瘤作用,能够明显抑制肺癌、肝癌、胃癌等细胞的发展并诱导其凋亡。现有研究表明DHM抗肿瘤机制主要有抑制肿瘤细胞周期、干预线粒通路以及对肿瘤相关信号通路的调控等途径。

关键词: 二氢杨梅素, 抗肿瘤, 机制

Abstract: Dihydromyricetin （DHM） is a polyphenolic hydroxy dihydroflavanols extracted from the stem and leaf of vine tea.Current pharmacology studies have shown that its anti-tumor effects can significantly inhibit the development of lung cancer, liver cancer, stomach cancer and other cells and induce their apoptosis. Existing studies have shown that the anti-tumor mechanisms of DHM mainly include inhibition of tumor cell cycle, intervention of mitochondrial pathways and regulation of tumor-related signaling pathways.

Key words: dihydromyricetin, mechanism, antuneoplastic

中图分类号:

R730.53

李作标, 蒋梁贵, 李明意. 二氢杨梅素的抗肿瘤机制研究进展[J]. 岭南现代临床外科, 2020, 20(03): 404-406.

LI Zuo-biao, JIANG Lian-gui, LI Ming-yi. Advances in research on anti-tumor mechanism of dihydromyricetin[J]. Lingnan Modern Clinics in Surgery, 2020, 20(03): 404-406.

参考文献

[1] Li H, Li Q, Liu Z, et al.The Versatile Effects of Dihydromyricetin in Health[J]. Evid Based Complement Alternat Med, 2017, (5): 1053617.
[2] 肖晓莹,陈继承,庞杰,等. 藤茶的功能性及黄酮类化合物提取研究进展[J]. 热带作物学报,2012, 33(8):1522-1527.
[3] 欧贤红,叶勇,黄秋洁,等. 藤茶抗氧化活性研究[J]. 天然产物研究与开发,2013, 25(2):245-248.
[4] 潘人琦,郁建平. 二氢杨梅素解酒作用的研究[J]. 山地农业生物学报,2012,31(3):247-249.
[5] 侯小龙,王文清,施春阳,等. 二氢杨梅素药理作用研究进展[J]. 中草药,2015,46(4):603-609.
[6] Correia C, Lee SH,Meng XW.Emerging understanding of Bcl-2 biology:Implications for neoplastic progression and treatment[J]. Bioehim Biophys Acta,2015,1853(7):1658-1671.
[7] 曹蕊. 中药对肿瘤细胞周期影响的研究进展[J]. 中国肿瘤临床,2012,39(10):749-752.
[8] Huang H, Hu M, Zhao R, et al.Dihydromyricetin suppresses the proliferation of hepatocellular carcinoma cells by inducing G2/M arrest through the Chk1/Chk2/Cdc25C pathway[J]. Oncol Rep,2013,30(5):2467-2475.
[9] 岑钧华. 二氢杨梅素诱导肝癌细胞株HepG2凋亡途径的探讨[J]. 实用医学杂志, 2014,30(8):1712-1715.
[10] Zhang J, Chen Y, Luo H, et al.Recent Update on the Pharmacological Effects and Mechanisms of Dihydromyricetin[J]. Front Pharmacol, 2018, 9: 1204.
[11] 周防震,张晓元,孙奋勇,郭勇. 二氢杨梅素对人乳腺癌细胞MDA-MB-231的体外抗增殖作用[J]. 肿瘤防治研究,2012, 39(1):95-97.
[12] 孙大永. 二氢杨梅素对非小细胞肺癌A549细胞体外抗肿瘤作用研究[J]. 解剖学报,2015, 46(3): 359-362.
[13] Zuo Y, Xu Q, Lu Y, et al.Dihydromyricetin induces apoptosis in a human choriocarcinoma cell line[J]. Oncol Lett, 2018, 16(4): 4229-4234.
[14] Chipuk JE, Mc Stay GP, Bharti A,et al.Sphingolipid metabolism cooperates with Bak and Bax to promote the mitochondrial pathway of apoptosis[J]. Cell, 2012, 148(5):988-1000.
[15] Yang Shu, Jie Liu, Mingyi Li, et al.Oncol Lett. Dihydromyricetin induces apoptosis and inhibits proliferation in hepatocellular carcinoma cells[J]. Oncol Lett, 2014, 8(4): 1645-1651.
[16] 王满英,丁小军,孙扬,等. 二氢杨梅素通过STAT3/Bcl-2信号通路促进HNSCC细胞自噬和凋亡[J]. 中国临床医学,2017,24(4):571-576
[17] Liu C,Zhao P,Yang Y,et al.Ampelopsin suppresses TNF-αinduced migration and invasion of U20Sosteosarcoma cells[J]. Mol Med Rep,2016,13(6):4729-4736.
[18] Wang K, Yang SF, Hsieh YH, et al.Effects of dihydromyricetin on ARPE-19 cell migration through regulating matrix metalloproteinase-2 expression[J]. Environ Toxicol, 2018, 33(12): 1298-1303.
[19] 周防震,张晓元,詹远京,等. 二氢杨梅素抑制人乳腺癌细胞侵袭和下调MMP-2/-9蛋白表达研究[J]. 生物化学与生物物理进展,2012,39(4):352-358.
[20] 邱志东,罗芳兰,舒洋,等. 二氢杨梅素对肝癌细胞黏附、侵袭及迁移的抑制作用及机制[J]. 中国普通外科杂志,2015,24(9):1263-1268.
[21] Zhang QY, Li R, Zeng GF, et al.Dihydromyricetin inhibits migration and invasion of hepatoma cells through regulation of MMP-9 expression[J]. World J Gastroenterol, 2014, 20(29): 10082-10093.
[22] 王凤杰,宗星煜,杜俊龙,等. 二氢杨梅素对人胃癌MKN45细胞迁移和侵袭的影响及其机制[J]. 中国应用生理学杂志,2019, 35(5):428-432.
[23] 王进峰,舒文云,祝宏斌,等. 二氢杨梅素联合顺铂显著诱导PC3中Noxa和Bim过表达[J].中国病理生理杂志,2018, 34(9):1610-1615.
[24] Jiang L, Zhang Q, Ren H, et al.Dihydromyricetin Enhances the Chemo-Sensitivity of Nedaplatin via Regulation of the p53/Bcl-2 Pathway in Hepatocellular Carcinoma Cells[J]. PLoS One, 2015, 10(4): e0124994.
[25] 吴明彩,蒋明,李大彩,等. 二氢杨梅素联合丝裂霉素对胃癌细胞的生长抑制作用[J]. 中国病理生理杂志,2011,27(7):1424-1427.
[26] He M, Zhang Q,Shu G,et al.Dihydromyricetin sensitizes human acute myeloid leukemia cells to retinoie acid-induced mye- loid differentiationby activating STAT1[J]. Biochem Biophys Res Commun,2018,495(2):1702-1707.