肝脏纤维化指数对原发性肝癌患者外科治疗后生存状况的影响

doi:10.3969/j.issn.1009-976X.2020.03.006

摘要/Abstract

摘要： 目的探讨肝脏纤维化指数（FI）对原发性肝癌患者外科治疗后生存状况的影响。方法选取2010年1月至2014年12月期间我院收治的82例行肝切除术的原发性肝癌患者为研究对象,根据术前血FI水平分为高纤维化程度组（FI>5.4,n=45）和低纤维化程度组（FI≤5.4,n=37）。采用Kaplan-Meier法计算两组患者的无瘤生存率,并采用log-rank检验进行比较。采用单因素与多因素Cox回归分析影响术后复发的有关危险因素。结果随访结果表明,全部患者的1、3、5年的无瘤生存率为79.7%、68.2%、32.7%。其中高肝纤维化组、低肝纤维化组的1、3、5年的无瘤生存率分别为69.8%、32.5%、21.6%与93.8%、45.3%、45.3%,差异有统计学意义（P<0.05）。多因素Cox回归分析结果表明术前AFP-L₃≥10%、FI>5.4、有脉管瘤栓及术后肝功能不全是患者术后复发的独立危险因素,差异有统计学意义（P<0.05）。结论术前FI>5.4是原发性肝癌患者术后复发的独立危险因素,对患者的预后具有一定的预测价值。

关键词: 生存状况, 复发, 肝纤维化指数, 原发性肝癌

Abstract: Objective To investigate the effect of liver fibrosis index （FI） on the survival status of patients with primary liver cancer after surgical treatment. Methods A total of 82 patients with primary liver cancer who underwent liver resection during our hospital from January 2010 to December 2014 were selected as the research subjects. They were divided into high fibrosis groups according to the preoperative blood FI level （FI>5.4, n=45） and low fibrosis group （FI≤5.4, n=37）. Kaplan-Meier method was used to calculate the tumor-free survival rate of the two groups of patients, and the log-rank test was used for comparison. The univariate and multivariate Cox regression analysis was used to analyze the relevant risk factors affecting postoperative recurrence. Results The follow-up results showed that the tumor-free survival rates of all patients at 1, 3, and 5 years were 79.7%, 68.2%, and 32.7%。 The 1-, 3-, and 5-year tumor-free survival rates of the high liver fibrosis group and the low liver fibrosis group were 69.8%, 32.5%, 21.6% and 93.8%, 45.3%, and 45.3%, respectively, and the differences were statistically significant （P<0.05）. Multivariate Cox regression analysis showed that preoperative AFP-L3≥10%, FI>5.4, vascular tumor thrombus and postoperative liver dysfunction were independent risk factors for postoperative recurrence, and the differences were statistically significant （P<0.05）. Conclusion Preoperative FI>5.4 is an independent risk factor for postoperative recurrence in patients with primary liver cancer, and has certain predictive value for the prognosis of patients.

Key words: survival status, primary liver cancer, relapse, liver fibrosis index

中图分类号:

R735.7

孙振芝. 肝脏纤维化指数对原发性肝癌患者外科治疗后生存状况的影响[J]. 岭南现代临床外科, 2020, 20(03): 296-299.

SUN Zhen-zhi. Effect of liver fibrosis index on survival of patients with primary hepatic cancer after surgical treatment[J]. Lingnan Modern Clinics in Surgery, 2020, 20(03): 296-299.

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