关键词: 术后并发症, 老年患者, 新辅助治疗, 改良衰弱指数, 腹腔镜直肠癌手术

Abstract: ［Abstract］ Objective To evaluate the application of modified frailty index （mFI） in predicting short-term outcomes of elderly patients undergoing laparoscopic rectal cancer surgery after neoadjuvant therapy. Methods We collected 147 elderly patients who underwent laparoscopic rectal cancer surgery after neoadjuvant therapy in Guangzhou First People′s Hospital from January 2012 to June 2018. According to the preoperative mFI score， they were divided into non-weakening group （mFI < 0.29， 106 cases） and weakening group （mFI> 0.29， 41 cases）. The demographic data， operation-related data， short-term clinical efficacy and postoperative complications of the two groups were analyzed. Statistical analysis was carried out on the indicators. Results 27.9% of patients were assessed as weak. There were significant differences in hospitalization days， post-operative complications between the weakened group and the non-weakened group（13.7±8.6 vs 10.5±3.8 d，P=0.025；20/106 vs 16/14，P=0.011）. Conclusion Excessive mFI is an important index to predict the occurrence of complications after neoadjuvant therapy for rectal cancer patients. Preoperative mFI score for elderly patients with colorectal cancer is helpful to provide a reasonable basis for clinical diagnosis and treatment and reduce the incidence of complications after surgery.

Key words: modified frailty index, postoperative complications, aged patient, laparoscopic rectal cancer surgery, neoadjuvant therapy