关键词: CTRP3, 心血管事件, 冠心病, 经皮冠状动脉介入治疗

Abstract: ［Abstract］ Objective To investigate the relationship between C1q/TNF?related protein 3 （CTRP3） levels and cardiovascular adverse events after percutaneous coronary intervention（PCI） in patients with coronary heart disease. Methods 107 patients with coronary heart disease after PCI admitted to the department of cardiology from June 2016 to June 2017 were selected， regularly indwelling all patients with blood samples before treatment. According to the occurrence of adverse events within half a year after surgery， 42 patients with adverse events were selected as the observation group， and 65 patients without adverse events were selected as the control group， blood samples from the two groups of patients after half a year the operation were collected. The changes of inflammatory factors such as C1q/TNF?related protein 3 （CTRP3）， C?reactive protein （CRP）， interleukin?10 （IL?10） and tumor necrosis factor?α （TNF?α） were compared between the two groups before and after half a year treatment. Results The levels of CTRP3 and IL?10 in the observation group were significantly lower than those in the control group， the levels of TNF?α and CRP in the observation group were significantly higher than those in the control group （P<0.05） before treatment， but the levels of IL?6 in the two groups were not significantly different （P>0.05）. The levels of serum CTRP3 and IL?10 in the observation group after half a year treatment were lower than those in the control group， and CRP was higher than that in the control group （P<0.05）， there was no significant difference in TNF?α and IL?6 levels between the two groups （P>0.05）， and the levels of TNF?α， CRP， and IL?6 are higher than before intervention in both two group. Correlation analysis result showed that there is a positive correlation between CTRP3 and IL?10 levels （r=0.615， P<0.001）， and a negative correlation with CRP levels （r=-0.737， P>0.001）. Conclusion There may be a negative correlation between CTRP3 and cardiovascular adverse events after interventional therapy in patients with coronary heart disease. The lower the level of CTRP3， the higher the incidence of cardiovascular adverse events. Therefore， it is of great clinical significance to regularly detect CTRP3 levels in patients undergoing coronary stent implantation.

Key words: coronary artery disease, CTRP3, percutaneous coronary intervention