关键词: 常规手动消毒, 中心静脉导管相关性血流感染, 消毒帽

Abstract: ［Abstract］ Objective To systematically evaluate the effects of antiseptic barrier cap use and manual disinfection on the incidence of CLABSIs. Methods The studies included were retrieved from Embase， Medline Ovid， Web?of?science， EBSCO， Cochrane Library， PubMed， CBM， CNKI， WANGFANG and VIP database until March 2， 2018. Two reviewers independently assessed the studies and extracted data. The primary outcome， reduction in CLABSIs per 1000 catheter?days， expressed as an incidence rate ratio （IRR）， was analyzed by RevMan 5.3. Results A total of 302 articles were identified as potentially relevant and after exclusion of duplicates， 176 articles were screened based on title and abstract|20 articles were read full text. Eventually， 11 studies were included in the systematic review， and nine of these 11 in the random effects meta? analysis. The pooled IRR showed that use of the antiseptic barrier cap was effective in reducing CLABSIs （IRR=0.60， 95%CI=0.52-0.70， P<0.0001）. Conclusion Use of an antiseptic barrier cap is associated with a lower incidence CLABSIs and is an intervention worth adding to central?line maintenance bundles.

Key words: Central line?associated bloodstream infections, Antiseptic barrier cap, Manual disinfection