关键词: I?125粒子, 胃癌, 核因子κB

Abstract: ［Abstract］ Objective To investigate the mechanism of Iodine?125 seed refraining the growth of tumors cell by hindering the expression of NF?kB stomach carcinoma cells. Methods The animal models with the stomach carcinoma cells （SGC?7901） were established by subcutaneously injecting the tumor cells into nude mice. When the tumors were fully established， the animals were randomly assigned to groups. There was no significant difference in average tumor size between groups. The mice of experiment group were intravenously administered Iodine?125 seed （0.6 MBq， n=30） and mice intravenously administered 0 MBq of Iodine?125 seed were used as blank control grpup （n=30）. The controls were nothing for implantation （n=30）. The size of tumors was measured every two days and their volumes then were calculated. Anatomy analysis were done separately after 28 days of the implantation of the Iodine?125 seeds|the mRNA and proteinum expressions of NF?kB were measured by the ways of RT?PCR and immunohistochemistry. Results After Iodine?125 seeds were transplanted into the tumors of the experimental animals， tumors grew more slowly， and the tumor inhibitory rate was 38% （control group） and 43% （experimental group）. After the 28 days， the mRNA and protein express level of NF?kB in tumors were significantly decreased in experimental groups. There was significant difference between the three groups （P<0.01）. Conclusions It is one of important molecular biology mechanisms to restrain stomach carcinoma with iodine?125 seeds to decreass the expression of NF?kB in tumor cells.

Key words: stomach carcinoma, nuclear factor kappa B（NF?κB）, Iodine?125 Seeds